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首页> 外文期刊>Allergy >Markers of eosinophilic and neutrophilic inflammation in bronchoalveolar lavage of asthmatic and atopic children.
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Markers of eosinophilic and neutrophilic inflammation in bronchoalveolar lavage of asthmatic and atopic children.

机译：哮喘和特应性儿童支气管肺泡灌洗中嗜酸性和嗜中性炎症的标志。

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BACKGROUND: Recent studies performing fiberoptic bronchoscopy in children have improved our understanding of asthma pathophysiology. Eosinophilic, but also neutrophilic, inflammation has been described in asthma, but the relationship with atopy was incompletely investigated. The aim of this study is to examine inflammatory cells and mediators in children with asthma compared to the appropriate controls, i.e. atopic children without asthma and children with no atopy or asthma. Moreover, asthmatic children were analysed separately based on the presence of atopy and stratified by age. METHODS: We recruited 191 children undergoing fiberoptic bronchoscopy for appropriate indications: 91 asthmatics (aged 1.4-17 years), 44 atopics without asthma (1.6-17.8 years) and 56 nonasthmatic nonatopic controls (1.4-14 years). In bronchoalveolar lavage, total and differential cell counts and inflammatory mediators, including ECP, eotaxin, IL-8 and TNFalpha, were analysed. RESULTS: Eosinophils and ECP levels were increased in asthmatic children when compared to controls (P = 0.002 and P = 0.01, respectively), but also atopic children without asthma had increased ECP levels compared to controls (P = 0.0001). Among asthmatic children, eosinophils and ECP levels were not different between atopic and nonatopic individuals. Neither neutrophils nor the related mediators (IL-8 and TNFalpha) differed significantly in the three groups. This pattern of inflammation was observed in both preschool and school-aged asthmatic children. CONCLUSIONS: This study suggests that markers of eosinophilic, but not neutrophilic inflammation, are increased in asthmatic children and also in atopic children without asthma. Of interest, in asthmatic children, the activation of the eosinophilic response is not solely because of the presence of atopy.
机译：背景：最近对儿童进行纤维支气管镜检查的研究提高了我们对哮喘病理生理学的认识。哮喘中已经描述了嗜酸性和嗜中性炎症，但尚未完全研究其与特应性的关系。这项研究的目的是检查哮喘患儿与适当对照相比的炎症细胞和介质，即无哮喘的特应性儿童和无特应性或哮喘的儿童。此外，根据特应性的存在情况对哮喘儿童进行单独分析，并按年龄分层。方法：我们招募了191例接受纤维支气管镜检查的儿童，以适应他们的适应症：91例哮喘患者（1.4-17岁），44例无哮喘的异位性哮喘（1.6-17.8岁）和56例非哮喘性非异位对照者（1.4-14岁）。在支气管肺泡灌洗中，分析了总细胞数和差异细胞数以及炎性介质，包括ECP，嗜酸性粒细胞趋化因子，IL-8和TNFalpha。结果：与对照组相比，哮喘儿童的嗜酸性粒细胞和ECP水平升高（分别为P = 0.002和P = 0.01），而与哮喘相比，无哮喘的特应性儿童的ECP水平也升高（P = 0.0001）。在哮喘儿童中，特应性和非特应性个体的嗜酸性粒细胞和ECP水平没有差异。在这三组中，中性粒细胞或相关介质（IL-8和TNFalpha）均无显着差异。在学龄前和学龄期哮喘儿童中都观察​​到这种炎症模式。结论：这项研究表明，在哮喘儿童和无哮喘的特应性儿童中，嗜酸性而非嗜中性炎症的标志物增加。有趣的是，在哮喘儿童中，嗜酸性粒细胞反应的激活不仅是由于特应性的存在。

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