Relationship between type 1 diabetes and atopic diseases in a twin population.

Thomsen SF; Duffy DL; Kyvik KO; Skytthe A; Backer V

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Relationship between type 1 diabetes and atopic diseases in a twin population.

机译：双胞胎人群中1型糖尿病与特应性疾病之间的关系。

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AIM: To study the association between type 1 diabetes and atopic diseases in a twin population. METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age. RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009. CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders.

机译：目的：研究双胞胎人群中1型糖尿病与特应性疾病之间的关系。方法：我们进行了问卷调查定义的特应性皮炎，哮喘和花粉症之间的联系，并记录了54530名丹麦双胞胎，3至71岁的出院诊断为1型糖尿病。结果：与非糖尿病患者相比，患有1型糖尿病的患者经年龄和性别调整的特应性皮炎的风险降低了（2.1％vs 9.9％），优势比（OR）= 0.23（0.07-0.71），P = 0.011 ，而哮喘和花粉症与1型糖尿病没有显着相关。在与1型糖尿病不一致的双胞胎对中，相对于非糖尿病双胞胎，糖尿病双胞胎患特应性皮炎的风险较低。特应性皮炎和1型糖尿病的遗传因素呈负相关（r = -0.30），P = 0.0009。结论：这些发现证实了1型糖尿病和特应性皮炎的Th1与Th2细胞二分法，并表明这些疾病的遗传因素之间呈负相关。

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《Allergy》 |2011年第5期|共3页
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Thomsen SF; Duffy DL; Kyvik KO; Skytthe A; Backer V;
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1. Relationship between type 1 diabetes and atopic diseases in a twin population. [J] . Thomsen SF, Duffy DL, Kyvik KO, Allergy . 2011,第5期

机译：双胞胎人群中1型糖尿病与特应性疾病之间的关系。
2. Centenary Celebration for Scottish Missionary Mary Slessor: A Lasting Legacy for Twins/Twin Research: Twins With Kleinfelter's Syndrome; Twin Research on Atopic Diseases; Twin Study of Autism; Psychotherapy with Twins/General Interest: Female Twin Pole-Vaulters; Longest Twin Birth Interval; Pair of Franco-Cuban Vocalists; Croatian Twin Models [J] . Segal, Nancy L. Twin research and human genetics : . 2015,第3期

机译：苏格兰传教士玛丽·史莱索（Mary Slessor）百年庆典：双胞胎/双胞胎研究的持久遗产：双胞胎伴克莱因费尔特氏综合症;关于特应性疾病的双重研究;对自闭症的双重研究;双胞胎心理疗法/一般兴趣：女性双胞胎撑竿跳高运动员;最长双胞胎间隔;一对法古两国歌唱家;克罗地亚双胞胎模特
3. Monocyte Gene-Expression Profiles Associated With Childhood-Onset Type 1 Diabetes and Disease Risk: A Study of Identical Twins [J] . Huriya Beyan Roosmarijn C Drexhage Leonie van der Heul Nieuwenhuijsen Harm de Wit Roosmarijn C Padmos Nanette C Schloot Hemmo A Drexhage Richard David Leslie Diabetes . 2010,第7期

机译：与儿童期1型糖尿病和疾病风险相关的单核细胞基因表达谱：相同双胞胎的研究
4. Relationship between Serum Lipid Index, C Reaction Protein (CRP), Insulin Resistance and Coronary Artery Disease in Diabetes Mellitus Patients Complicated with Coronary Atherosclerotic Heart Disease (CAHD) and Correlation Analysis [C] . Hui Li, Zhanhua Li, Fanjin Zeng, International Conference on Education, Social Science, Management and Sports . 2017

机译：糖尿病患者糖尿病患者血清脂指数，C反应蛋白（CRP），胰岛素抵抗和冠状动脉疾病的关系及冠状动脉粥样硬化（CAHD）和相关分析
5. The development of Type 2 diabetes mellitus (Type 2 DM) in California twins. [D] . Tsai, Pei-Jung. 2011

机译：加利福尼亚双胞胎的2型糖尿病（2型糖尿病）的发展。
6. Monocyte Gene-Expression Profiles Associated With Childhood-Onset Type 1 Diabetes and Disease Risk: A Study of Identical Twins [O] . Huriya Beyan, Roosmarijn C. Drexhage, Leonie van der Heul Nieuwenhuijsen, 2010

机译：与儿童期1型糖尿病和疾病风险相关的单核细胞基因表达谱：相同双胞胎的研究
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Relationship between type 1 diabetes and atopic diseases in a twin population.

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