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New topics in bradykinin research.

机译:缓激肽研究的新话题。

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摘要

Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B(1) and B(2) receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.
机译:缓激肽被认为与过敏性炎症和过敏性疾病的发病机理有关。它与内皮B(1)和B(2)受体结合,并发挥强大的药理和生理作用,特别是降低血压,增加血管通透性和促进炎症的经典症状,如血管舒张,热疗,水肿和疼痛。为了获得潜在的临床益处,缓激肽还显示出有效的抗血栓形成,抗增殖和抗纤维化作用。缓激肽受体阻滞剂等药理活性物质的开发开辟了新的治疗选择,需要进一步研究缓激肽。这篇综述提供了关于缓激肽在非过敏性血管性水肿和过敏症患者和急诊医师所见的其他病症中的作用的当前理解,以及其作为治疗靶标的潜在作用。

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