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首页> 外文期刊>Allergy >Adaptive T-cell responses regulating oral tolerance to protein antigen.
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Adaptive T-cell responses regulating oral tolerance to protein antigen.

机译：调节口腔对蛋白抗原的耐受性的适应性T细胞反应。

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The term oral (or mucosal) tolerance has been classically defined as the suppression of T- and B-cell responses to an antigen by prior administration of the antigen by the oral route. In recent years, it has become clear that both innate and acquired regulatory immune responses are essential for the development of oral tolerance. As such, mucosal microenvironmental factors such as transforming growth factor- beta, prostaglandins but also dietary vitamin A create conditioning of an adaptive regulatory T-cell response that suppresses subsequent antigen-specific responses. Particular resident subsets of antigen presenting dendritic cells are pivotal to convey conditioning signals next to the presentation of antigen. This review discusses the primary mechanisms of adaptive regulatory T-cell induction to ingested soluble protein antigen. However, we also discuss the limitations of our knowledge with respect to understanding the very common food hypersensitivity Celiac disease caused by an aberrant adaptive immune response to the food protein gluten.
机译：术语口服（或粘膜）耐受性已经典地定义为通过事先通过口服途径施用抗原来抑制对抗原的T细胞和B细胞应答。近年来，已经清楚的是，先天性和后天性调节免疫应答对于口服耐受性的发展都是必不可少的。这样，粘膜微环境因子（例如转化生长因子-β，前列腺素以及饮食中的维生素A）会产生适应性调节性T细胞反应的条件，从而抑制随后的抗原特异性反应。抗原呈递树突状细胞的特定常驻亚群是关键的，以便在抗原呈递之后传递条件信号。这篇综述讨论了对摄取的可溶性蛋白抗原的适应性调节性T细胞诱导的主要机制。但是，我们还讨论了关于了解非常常见的食物超敏性腹腔疾病所致知识的局限，这种疾病是由对食物蛋白麸质的异常适应性免疫反应引起的。

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