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首页> 外文期刊>Allergy >Infant eczema, infant sleeping problems, and mental health at 10 years of age: the prospective birth cohort study LISAplus.
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Infant eczema, infant sleeping problems, and mental health at 10 years of age: the prospective birth cohort study LISAplus.

机译：婴儿湿疹，婴儿睡眠问题和10岁以下的心理健康：前瞻性出生队列研究LISAplus。

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BACKGROUND: Cross-sectional studies suggest an association between eczema and mental health problems, possibly modified by sleeping problems, but prospective evidence is missing. We aimed to prospectively investigate the relationship between infant eczema (within first 2 years of age), infant sleeping problems (within first 2 years of age), and the risk of mental health problems at 10 years of age. METHODS: Between 1997 and 1999, a population-based birth cohort was recruited in Munich, Leipzig, Wesel, and Bad Honnef, Germany, and followed until 10 years of age. Physician-diagnosed eczema, parent-reported sleeping problems, and known environmental risk factors for atopy were regularly assessed until 10 years of age. Mental health was measured using the Strengths and Difficulties Questionnaire (parent version) at 10 years of age. We applied logistic regression modeling adjusting for environmental and lifestyle factors, allergic comorbidity, and family history of eczema. RESULTS: From the original cohort of 3097 neonates, 1658 (54%) were followed until age 10, while 1578 (51%) were eligible for analysis. In the fully adjusted model, children with infant eczema were at increased risk of hyperactivity/inattention at 10 years of age [odds ratio (OR) 1.78; 95% confidence interval (95% CI) 1.02-3.09]. Infant eczema with concurrent sleeping problems predicted emotional problems [OR 2.63; 95% confidence interval (95% CI) 1.20-5.76] and conduct problems (OR 3.03; 95% CI 1.01-9.12) at 10 years of age. CONCLUSIONS: Infant eczema with concurrent sleeping problems appears to be a risk factor for the development of mental health problems.
机译：背景：横断面研究表明，湿疹与精神健康问题之间可能存在睡眠障碍，可能会改变这种关系，但缺少前瞻性证据。我们旨在前瞻性地调查婴儿湿疹（头2岁以内），婴儿睡眠问题（头2岁以内）与10岁以下的精神健康风险之间的关系。方法：1997年至1999年之间，在慕尼黑，莱比锡，韦瑟尔和德国巴特洪内夫市招募了一个以人口为基础的出生队列，并随访至10岁。定期评估医生诊断出的湿疹，父母报告的睡眠问题以及已知的特应性环境危险因素，直至10岁。使用“强项和困难问卷”（父母版本）在10岁时测量心理健康。我们应用逻辑回归模型调整了环境和生活方式因素，过敏性合并症和湿疹家族史。结果：从最初的3097名新生儿队列中，随访1658名（54％）至10岁，而1578名（51％）有资格进行分析。在完全调整的模型中，婴儿湿疹的儿童在10岁时发生多动/注意力不足的风险增加[比值比（OR）1.78; 95％置信区间（95％CI）1.02-3.09]。婴儿湿疹并发的睡眠问题预示了情绪问题[OR 2.63; 95％置信区间（95％CI）1.20-5.76]，并在10岁时出现问题（OR 3.03; 95％CI 1.01-9.12）。结论：婴儿湿疹并发性睡眠问题似乎是导致精神健康问题的危险因素。

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