Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis.

Niedoszytko M; Bruinenberg M; van Doormaal JJ; de Monchy JG; Nedoszytko B; Koppelman GH; Nawijn MC; Wijmenga C; Jassem E; Elberink JN

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Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis.

机译：基因表达分析预测在惰性系统性肥大细胞增多症中昆虫毒液过敏。

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BACKGROUND: Anaphylaxis to insect venom (Hymenoptera) is most severe in patients with mastocytosis and may even lead to death. However, not all patients with mastocytosis suffer from anaphylaxis. The aim of the study was to analyze differences in gene expression between patients with indolent systemic mastocytosis (ISM) and a history of insect venom anaphylaxis (IVA) compared to those patients without a history of anaphylaxis, and to determine the predictive use of gene expression profiling. METHODS: Whole-genome gene expression analysis was performed in peripheral blood cells. RESULTS: Twenty-two adults with ISM were included: 12 with a history of IVA and 10 without a history of anaphylaxis of any kind. Significant differences in single gene expression corrected for multiple testing were found for 104 transcripts (P < 0.05). Gene ontology analysis revealed that the differentially expressed genes were involved in pathways responsible for the development of cancer and focal and cell adhesion suggesting that the expression of genes related to the differentiation state of cells is higher in patients with a history of anaphylaxis. Based on the gene expression profiles, a naive Bayes prediction model was built identifying patients with IVA. CONCLUSIONS: In ISM, gene expression profiles are different between patients with a history of IVA and those without. These findings might reflect a more pronounced mast cells dysfunction in patients without a history of anaphylaxis. Gene expression profiling might be a useful tool to predict the risk of anaphylaxis on insect venom in patients with ISM. Prospective studies are needed to substantiate any conclusions.

机译：背景：肥大细胞增多症患者对昆虫毒液（膜翅目）的过敏反应最为严重，甚至可能导致死亡。但是，并非所有肥大细胞增多症患者都患有过敏反应。这项研究的目的是分析无系统性全身肥大细胞增多症（ISM）和有昆虫毒液过敏史（IVA）的患者与无过敏史的患者之间基因表达的差异，并确定基因表达的预测用途分析。方法：在外周血细胞中进行全基因组基因表达分析。结果：包括22位ISM成人：12位具有IVA病史和10位无任何过敏反应史。发现针对104个转录本进行多次测试校正后的单基因表达存在显着差异（P <0.05）。基因本体分析表明，差异表达的基因参与了导致癌症发展，病灶和细胞粘附的途径，这表明有过敏史的患者与细胞分化状态相关的基因表达更高。基于基因表达谱，建立了朴素的贝叶斯预测模型来鉴定IVA患者。结论：在ISM中，有IVA病史的患者和没有IVA史的患者的基因表达谱是不同的。这些发现可能反映出无过敏史的患者中肥大细胞功能异常更为明显。基因表达谱分析可能是预测ISM患者对昆虫毒液过敏的风险的有用工具。需要进行前瞻性研究以证实任何结论。

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《Allergy》 |2011年第5期|共10页
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Niedoszytko M; Bruinenberg M; van Doormaal JJ; de Monchy JG; Nedoszytko B; Koppelman GH; Nawijn MC; Wijmenga C; Jassem E; Elberink JN;
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中图分类医学免疫学;
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1. Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis. [J] . Niedoszytko M, Bruinenberg M, van Doormaal JJ, Allergy . 2011,第5期

机译：基因表达分析预测在惰性系统性肥大细胞增多症中昆虫毒液过敏。
2. Gene expression profile, pathways, and transcriptional system regulation in indolent systemic mastocytosis. [J] . Niedoszytko M, Oude Elberink JN, Bruinenberg M, Allergy . 2011,第2期

机译：在惰性系统性肥大细胞增多症中的基因表达谱，途径和转录系统调控。
3. Gene expression analysis in predicting the effectiveness of insect venom immunotherapy. [J] . Niedoszytko M, Bruinenberg M, de Monchy J, The Journal of Allergy and Clinical Immunology . 2010,第5期

机译：基因表达分析预测昆虫毒液免疫治疗的有效性。
4. Anti-IgE Treatment Overcomes Intolerability of Honeybee- Venom Ultra-Rush Immunotherapy in Indolent Systemic Mastocytosis [C] . B. Wedi, D. Wieczorek, U. Raap, Collegium Internationale Allergologicum . 2007

机译：抗IgE治疗克服了蜜腺超鼠疫免疫疗法在惰性全身乳细胞诱变中的不耐受性
5. A biochemical and molecular analysis of venom with distinct physiological actions from two arthropod sources: The parasitoid jewel wasp, Ampulex compressa, of the insect order Hymenoptera and the obligate entomophagous assassin bug, Platymeris biguttata, of the insect order Hemiptera. [D] . Moore, Eugene Lachlan. 2003

机译：毒液的生化和分子分析，具有两种不同节肢动物来源的独特生理学作用：寄生类黄蜂，昆虫纲膜翅目的Ampulex compressa和昆虫半翅目昆虫的专性食虫性刺客臭虫Platymeris biguttata。
6. Anaphylaxis and systemic mastocytosis. [O] . J C Brouet 1979

机译：过敏反应和全身肥大细胞增多症。
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Gene expression analysis predicts insect venom anaphylaxis in indolent systemic mastocytosis.

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