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首页> 外文期刊>Allergy >Prenatal negative life events increases cord blood IgE: Interactions with dust mite allergen and maternal atopy
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Prenatal negative life events increases cord blood IgE: Interactions with dust mite allergen and maternal atopy

机译：产前不良生活事件会增加脐血IgE：与尘螨过敏原和母源性特应性的相互作用

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Background Prenatal exposure to both stress and aeroallergens (dust mite) may modulate the fetal immune system. These exposures may interact to affect the newborn immune response. We examined associations between prenatal maternal stress and cord blood total IgE in 403 predominately low-income minority infants enrolled in the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project. We also examined potential modifying effects of maternal atopy and maternal dust mite exposure. Methods The Crisis in Family Systems survey was administered to mothers prenatally, and a negative life event domain score was derived to characterize stress. Dust mite allergen was quantified in dust from pregnant mothers' bedrooms. Cord blood was analyzed for total IgE. Using linear regression, we modeled the relationship of stress with cord blood IgE and interactions of stress with dust mite and/or maternal atopy, adjusting for potential confounders. Results Higher prenatal maternal stress (β = 0.09; P = 0.01) was associated with increased cord blood IgE. The interactive effects between stress and dust mite groups (high vs low) were significantly different for children of atopic vs nonatopic mothers (P for three-way interaction = 0.005). Among children of atopic mothers, the positive association between stress and IgE was stronger in the high dust mite group. In children of mothers without a history of atopy, the positive association between stress and IgE was most evident in the low allergen group. Conclusions Prenatal stress was independently associated with elevated cord blood IgE. Mechanisms underlying stress effects on fetal immunomodulation may differ based on maternal atopic status.
机译：背景产前暴露于压力和气态过敏原（尘螨）可能会调节胎儿的免疫系统。这些接触可能相互作用，影响新生儿的免疫反应。我们检查了403名以哮喘为主的社区，环境和社会压力联盟（ACCESS）项目的产前孕妇压力与脐带血总IgE之间的关联。我们还检查了母体特应性和母体尘螨暴露的潜在修饰作用。方法：对产前母亲进行了《家庭系统危机》调查，得出了生活事件领域得分为负值来表征压力。尘螨过敏原在孕妇卧室的尘埃中进行了定量。分析脐带血的总IgE。使用线性回归，我们对应激与脐带血IgE的关系以及应激与尘螨和/或母源性特应性的相互作用进行了建模，并针对潜在的混杂因素进行了调整。结果较高的产前产妇压力（β= 0.09; P = 0.01）与脐血IgE升高有关。特应性和非特应性母亲的孩子的压力和尘螨组之间的相互作用（高和低）明显不同（三向相互作用的P = 0.005）。在特应性母亲的孩子中，高尘螨组中压力与IgE之间的正相关性较强。在没有特应性病史的母亲的孩子中，低过敏原组中压力和IgE之间的正相关最为明显。结论产前应激与脐血IgE升高独立相关。压力对胎儿免疫调节的潜在作用机制可能会因母亲异位状态而异。

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