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首页> 外文期刊>Allergy >Glutathione-S-transferase P1, early exposure to mould in relation to respiratory and allergic health outcomes in children from six birth cohorts. A meta-analysis
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Glutathione-S-transferase P1, early exposure to mould in relation to respiratory and allergic health outcomes in children from six birth cohorts. A meta-analysis

机译：谷胱甘肽-S-转移酶P1，与六个出生队列儿童的呼吸道和过敏性健康结局相关的早期霉菌暴露。荟萃分析

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Background There are conflicting study results regarding the association of exposure to visible mould and fungal components in house dust with respiratory and allergic diseases in children. It has been suggested that functional polymorphisms of the GSTP1 gene may influence the risk for allergic disorders through an impaired defence against oxidant injury. Methods We examined in six birth cohorts of over 14 000 children whether the association between early exposure to reported mould at home in relation to respiratory and allergic diseases is modified by a single nucleotide polymorphism of the GSTP1 gene. Results We observed a positive association of mould exposure with nasal symptoms (2-10 year) aOR: 1.19 (1.02-11.38). Further, there was a borderline significant increased risk of rhinoconjunctivitis (6-8 year) in children homozygous for the minor allele Val/Val, aOR: 1.25 (0.98-1.60). In stratified analyses, subjects homozygous for the minor allele and exposed to mould at home were at increased risk for early wheezing aOR: 1.34 (1.03-1.75), whereas the major allele may confer susceptibility for later nasal outcomes, (6-8 year) aOR: 1.20 (1.00-1.45) and (2-10 year) aOR: 1.30 (1.04-1.61), respectively. For none of the health outcomes studied, we found gene by environment interactions. Conclusion A genetic influence of the GSTP1 gene cannot be ruled out, but the magnitude of the effect is a matter of further research. In conclusion, the interplay between gene and environments is complex and remains subject of further study. ? 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
机译：背景关于儿童房尘中可见霉菌和真菌成分的暴露与儿童呼吸道和过敏性疾病的关系，研究结果存在矛盾。有人认为，GSTP1基因的功能多态性可能通过削弱对氧化损伤的防御作用而影响过敏性疾病的风险。方法我们在六个出生队列中的14000多名儿童中研究了GSTP1基因的单核苷酸多态性是否改变了与呼吸道疾病和过敏性疾病相关的在家早期报告霉菌暴露的关联。结果我们观察到霉菌暴露与鼻部症状（2-10年）aOR呈正相关：1.19（1.02-11.38）。此外，在纯合子中，较小等位基因Val / Val，aOR：1.25（0.98-1.60）的儿童发生结膜炎（6-8岁）的危险显着增加。在分层分析中，次要等位基因纯合子并在家中暴露于霉菌的受试者发生早期喘息的风险增加：1.34（1.03-1.75），而主要等位基因可能会导致后期鼻塞的易感性（6-8岁） aOR：1.20（1.00-1.45）和（2-10年）aOR：1.30（1.04-1.61）。对于没有研究过的健康结果，我们通过环境相互作用发现了基因。结论不能排除GSTP1基因的遗传影响，但影响的大小有待进一步研究。总之，基因与环境之间的相互作用是复杂的，并且仍然是有待进一步研究的课题。 ？ 2013 John Wiley＆Sons A / S。由布莱克韦尔出版有限公司出版。

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