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Tree pollen allergens-an update from a molecular perspective

机译：树花粉过敏原-分子视角的更新

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摘要

It is estimated that pollen allergies affect approximately 40% of allergic individuals. In general, tree pollen allergies are mainly elicited by allergenic trees belonging to the orders Fagales, Lamiales, Proteales, and Pinales. Over 25 years ago, the gene encoding the major birch pollen allergen Bet v 1 was the first such gene to be cloned and its product characterized. Since that time, 53 tree pollen allergens have been identified and acknowledged by the WHO/IUIS allergen nomenclature subcommittee. Molecule-based profiling of allergic sensitization has helped to elucidate the immunological connections of allergen cross-reactivity, whereas advances in biochemistry have revealed structural and functional aspects of allergenic proteins. In this review, we provide a comprehensive overview of the present knowledge of the molecular aspects of tree pollen allergens. We analyze the geographic distribution of allergenic trees, discuss factors pivotal for allergic sensitization, and describe the role of tree pollen panallergens. Novel allergenic tree species as well as tree pollen allergens are continually being identified, making research in this field highly competitive and instrumental for clinical applications.
机译：据估计，花粉过敏影响约40％的过敏个体。通常，树花粉过敏主要是由属于Fagales，Lamiales，Proteales和Pinales的变应原树引起的。 25年前，编码主要桦树花粉变应原Bet v 1的基因是第一个被克隆并对其产物进行鉴定的基因。自那时以来，WHO / IUIS过敏原命名小组委员会已确认并确认了53种树花粉过敏原。基于分子的过敏性敏化分析有助于阐明过敏原交叉反应的免疫学联系，而生物化学方面的进展揭示了过敏原蛋白的结构和功能方面。在这篇综述中，我们提供了对树花粉过敏原分子方面当前知识的全面概述。我们分析了过敏树的地理分布，讨论了过敏致敏的关键因素，并描述了树花粉致敏物的作用。新型致敏树种以及花粉过敏原正在不断被发现，这使得该领域的研究在临床应用中具有很高的竞争性和实用性。

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