...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >Two different profiles of peach allergy in the north of Spain.
【24h】

Two different profiles of peach allergy in the north of Spain.

机译：桃子过敏的两个不同外形在西班牙的北部的。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Peach allergy has two different patterns: central Europe with oral allergy syndrome (OAS) related to a primary sensitization to birch pollen Bet v 1 and profilins and southern Europe with mostly systemic symptoms, in many cases due to sensitization to lipid-transfer proteins. METHODS: Thirty peach-allergic patients with positive skin and food challenge tests and 29 control subjects were included. Skin prick tests (SPT) with inhalant allergens, commercial peach and apple extracts and native Pru p 3 were performed. In vitro specific immunoglobulin (Ig) E to grass pollen, birch pollen, peach, apple, rBet v 1, rBet v 2 and rPhl p 12 was determined by CAP, and rBet v 1, rMal d 1, rMal d 4, rMal d 3 and rPru p 3 using the ADVIA-Centaur platform. Basophil activation test (BAT) with commercial peach extract, commercial apple extract, nPru p 3, rMal d 3, rMal d 1 and rMal d 4 was also performed. RESULTS: Pru p 3 was the major allergen in the patient group from northern Spain. Sensitization to this allergen was found in 100% of the patients with systemic symptoms or contact urticaria. Only 60% of OAS patients were sensitized to Pru p 3, being all of them sensitized to profilins and 60% of them to allergens of the Bet v 1 family. Specific IgE determination and BAT using recombinant allergens (rPru p 3) show specificity and sensitivity values close to 100%. CONCLUSIONS: Most peach-allergic patients coming from the north of Spain present systemic symptoms after ingestion of peach, Pru p 3 being the main allergen. Patients with OAS present profilin-Bet v 1-related sensitization. Thus, in the north of Spain our patients show a mixed central-south Europe pattern with LTP-profilin-Bet v 1 sensitization depending on the symptoms presented. The use of natural and recombinant plant allergens, allows establishing the sensitization patterns to the different allergens studied.
机译：背景：桃子过敏有两种不同的模式：中欧伴有对桦木花粉Bet v 1和脯氨酸蛋白原发性致敏的口腔过敏综合症（OAS），以及在南欧大多数情况下是全身性​​症状，在许多情况下是由于对脂质转移蛋白致敏。方法：30名桃过敏症患者的皮肤和食物激发试验阳性，并纳入29名对照受试者。使用吸入性过敏原，市售桃子和苹果提取物以及天然Pru p 3进行皮肤点刺试验（SPT）。通过CAP测定草花粉，桦树花粉，桃子，苹果，rBet v 1，rBet v 2和rPhl p 12的体外特异性免疫球蛋白（Ig）E，并确定rBet v 1，rMal d 1，rMal d 4，rMal d 3和rPru p 3使用ADVIA-Centaur平台。还用商品桃子提取物，商品苹果提取物，nPru p 3，rMal d 3，rMal d 1和rMal d 4进行了嗜碱性粒细胞活化测试（BAT）。结果：Pru p 3是西班牙北部患者组中的主要过敏原。在有全身症状或接触性荨麻疹的患者中，有100％对这种过敏原敏感。只有60％的OAS患者对Pru p 3敏感，他们全部对profilins敏感，而60％对Bet v 1家族的过敏原敏感。使用重组变应原的特异性IgE测定和BAT（rPru p 3）显示特异性和敏感性值接近100％。结论：大多数来自西班牙北部的桃子过敏患者在摄入桃子后会出现全身症状，Pru p 3是主要的过敏原。 OAS患者表现出profilin-Bet v 1相关的致敏作用。因此，在西班牙北部，根据出现的症状，我们的患者表现出中南欧洲混合型，LTP-profilin-Bet v 1致敏。天然和重组植物过敏原的使用，可以建立对所研究的不同过敏原的敏化模式。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号