...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes.
【24h】

Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes.

机译：嗜酸性粒细胞阳离子蛋白（ECP）多态性与哮喘，s-ECP水平和相关表型的关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Eosinophil cationic protein (ECP) is a potent cytotoxic secretory protein with bactericidal and antiviral properties. ECP is released by activated eosinophils and regarded as a marker of eosinophilic inflammation. High levels of ECP have been reported in cases of active asthma and other allergic diseases. This study aimed to assess whether three single-nucleotide polymorphisms (SNPs) in the ECP gene (RNASE3) on chromosome 14 q24-q31 or their haplotypes are associated with asthma, allergy, or related phenotypes. METHODS: The three SNPs -38CA, +371CG and +499CG in RNASE3 and their haplotypes were analyzed for associations with asthma, serum-ECP (s-ECP) levels, allergic sensitization (positive skin-prick test to common allergens), bronchial hyperresponsiveness (BHR) assessed by methacholine inhalation, and serum-IgE (s-IgE) levels in 177 families from Norway and the Netherlands identified through siblings with asthma. RESULTS: Transmission disequilibrium test (TDT) demonstrated significant associations between the A-G-G haplotype and asthma as well as the specific phenotypes allergic asthma (but not non-allergic asthma), high s-ECP, high s-IgE and BHR, while the C-G-G haplotype was associated with reduced occurrence of these traits. In addition, the -38A allele was associated with high s-ECP levels and allergic asthma. CONCLUSION: The present study suggests that the A-G-G haplotype in the RNASE3 gene influences the development of asthma, in particular, an allergic form of asthma. Furthermore, as the -38CA SNP lies in close vicinity of known intron-regulatory sites, results of SNP analysis suggest that the detected association is possibly linked to a genetic transcriptional control of s-ECP levels.
机译：背景：嗜酸性粒细胞阳离子蛋白（ECP）是一种具有杀菌和抗病毒特性的有效细胞毒性分泌蛋白。 ECP由活化的嗜酸性粒细胞释放，并被视为嗜酸性炎症的标志。在活动性哮喘和其他过敏性疾病中，ECP含量较高。这项研究旨在评估14号染色体q24-q31上ECP基因（RNASE3）中的三个单核苷酸多态性（SNP）或它们的单倍型是否与哮喘，过敏或相关表型有关。方法：分析了RNASE3中的三个SNP -38CA，+ 371CG和+ 499CG及其单倍型与哮喘，血清ECP（s-ECP）水平，过敏性致敏（对常见过敏原的阳性皮肤点刺试验），支气管高反应性的相关性通过乙酰甲胆碱吸入和通过哮喘兄弟姐妹鉴定的来自挪威和荷兰的177个家庭的血清IgE（s-IgE）水平评估（BHR）。结果：传输不平衡测试（TDT）表明AGG单倍型与哮喘以及过敏性哮喘的特定表型（而非非过敏性哮喘），高s-ECP，高s-IgE和BHR之间存在显着关联，而CGG单倍型与减少这些特征的发生有关。此外，-38A等位基因与高s-ECP水平和过敏性哮喘有关。结论：本研究提示RNASE3基因中的A-G-G单倍型会影响哮喘的发展，特别是哮喘的变态反应形式。此外，由于-38CA SNP位于已知的内含子调节位点附近，SNP分析的结果表明，检测到的关联可能与s-ECP水平的遗传转录控制有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号