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首页> 外文期刊>Allergy >Association between a genetic variation of CC chemokine receptor-2 and atopic asthma.
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Association between a genetic variation of CC chemokine receptor-2 and atopic asthma.

机译:CC趋化因子受体2的遗传变异与特应性哮喘之间的关联。

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摘要

Asthma is phenotypically heterogeneous, and studies have provided evidence of different patterns of inflammatory cell involvement in atopic and nonatopic asthma, which suggests that these two subtypes of asthma involve distinct im- munopatho-logical processes (1). A coordinated network of chemokines and chemokine receptors plays a key role in the generation of thecomplex pathology of asthma (2). It is known that Th 1 -type cells differentially express CXC chemokine receptor (CXCR)-3 and CC chemokine receptor (CCR)-5, while Th2-type cells express CCR3, CCR4, and CCR8 (2). In this study, to evaluate the notion that nonsynonymous coding single nucleotide polymorphisms (cSNPs) in CCRs are associated with the prevalence of asthma, we performed a population-based case-control study to evaluate the associations between nonsynonymous SNPs of CCRs and asthma in a Korean population.
机译:哮喘在表型上是异质性的,研究提供了异位性哮喘和非特应性哮喘中炎症细胞受累模式不同的证据,这表明哮喘的这两种亚型涉及不同的免疫病理学过程(1)。趋化因子和趋化因子受体的协调网络在哮喘复杂病理的产生中起关键作用(2)。已知Th 1型细胞差异表达CXC趋化因子受体(CXCR)-3和CC趋化因子受体(CCR)-5,而Th2型细胞表达CCR3,CCR4和CCR8(2)。在这项研究中,为了评估CCR中非同义编码单核苷酸多态性(cSNPs)与哮喘患病率有关的观念,我们进行了一项基于人群的病例对照研究,以评估CCR中非同义SNP与哮喘的关联性。韩国人口。

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