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Relationship between asthma and cognition: The cooper center longitudinal study

机译：哮喘与认知的关系：库珀中心纵向研究

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Background: Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods: We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable. Results: When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1/FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score. Conclusions: In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.
机译：背景：关于哮喘与认知能力之间关系的最小数据可用。在本报告中，我们研究了哮喘与老年人认知能力之间的关系，老年人是认知障碍风险升高的亚人群。方法：我们对德克萨斯州达拉斯市库珀诊所完成预防性健康检查的1380名年龄≥55岁的参与者进行了横断面，回顾性分析。使用蒙特利尔认知评估（MoCA）评估认知度，这是对轻度认知障碍的简短测试。使用暗示认知障碍的MoCA得分作为因变量，在多元逻辑回归中分析数据。结果：根据MoCA评分，在控制人口统计学特征，自我评估的健康状况，吸入糖皮质激素的使用以及FEV1 / FVC时，哮喘与认知障碍风险增加78％（P = 0.02）相关。结论：在迄今为止最大的样本中，我们发现了哮喘与老年人认知障碍之间的显着关系。

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