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首页> 外文期刊>Allergy >Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis.
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Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis.

机译：间歇性变应性鼻炎患者的鼻液Clara细胞蛋白16水平与变态反应性鼻炎的症状和体征之间呈负相关。

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Background: Decreased levels of the anti-inflammatory Clara Cell Protein 16 (CC16) are found in intermittent allergic rhinitis (IAR) and asthma. In asthma this decrease has been associated with hyperreactivity and the A38G single nucleotide polymorphism (SNP). The aim of this study was to examine if IAR is associated with signs and symptoms of rhinitis and the A38G SNP. Methods: Nasal fluid CC16 was analyzed in 20 patients with IAR before allergen challenge and 1 and 6 h after challenge, and from 28 healthy controls. The A38G SNP was analyzed in 80 patients with IAR and 106 controls. Nasal biopsies were obtained from three subjects in each group for immunohistochemical analysis of CC16. Results: In the allergen-challenged patients symptoms and rhinoscopic signs of rhinitis increased after 1 h and normalized after 6 h. In contrast, nasal fluid CC16 decreased 1 h after allergen challenge and returned to baseline after 6 h. Nasal fluid CC16 levels did not differ from controls before and 6 h after challenge. Immunohistochemical investigation showed intense CC16 staining in the nasal epithelium of both patients before season and healthy controls, but weak staining in symptomatic patients during season. No significant association between the A38G SNP and IAR was found. Conclusion: There was an inverse relation between nasal fluid CC16 levels and symptoms and signs of rhinitis in allergen-challenged patients with IAR. However, there was no association between IAR and the A38G SNP.
机译：背景：在间歇性变应性鼻炎（IAR）和哮喘中发现抗炎性克拉拉细胞蛋白16（CC16）水平降低。在哮喘中，这种减少与高反应性和A38G单核苷酸多态性（SNP）有关。这项研究的目的是检查IAR是否与鼻炎和A38G SNP的体征和症状有关。方法：对28名健康对照者在过敏原激发前，激发后1、6小时对IAR患者的鼻液CC16进行了分析。分析了80例IAR患者和106例对照的A38G SNP。从每组中的三名受试者获得鼻活检，以用于CC16的免疫组织化学分析。结果：在变应原激发的患者中，鼻炎的症状和鼻镜检查症状在1小时后增加，在6小时后恢复正常。相比之下，变应原攻击后1 h，鼻液CC16下降，而在6 h后，鼻液CC16返回基线。鼻液CC16水平在攻击前和攻击后6小时与对照组无差异。免疫组织化学研究显示，季节和健康对照组的患者鼻上皮均出现强烈的CC16染色，而有症状的患者在季节中的鼻腔染色较弱。在A38G SNP和IAR之间未发现明显关联。结论：变应原性IAR患者鼻液CC16水平与鼻炎症状和体征呈负相关。但是，IAR和A38G SNP之间没有关联。

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