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首页> 外文期刊>Allergy >The diagnostic accuracy of specific IgE to Ara h 6 in adults is as good as Ara h 2
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The diagnostic accuracy of specific IgE to Ara h 6 in adults is as good as Ara h 2

机译：成人特异性IgE对Ara h 6的诊断准确性与Ara h 2一样好

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摘要

Specific IgE (sIgE) to Ara h 2 is useful in diagnosing peanut allergy. Our aim was to assess the diagnostic value of sIgE to Ara h 6, another 2S albumin, in an adult population suspected of peanut allergy. Subjects with suspected peanut allergy between 2002 and 2013 were included if a diagnostic double-blind, placebo-controlled food challenge with peanut was performed. sIgE to Ara h 2 and Ara h 6 was measured by ImmunoCAP ISAC 112. Of 107 challenged subjects, 65 had a positive challenge (61%). The discriminative ability of sIgE to Ara h 2 and Ara h 6 was comparable: AUC 0.81 vs 0.82. Positive predictive value for both tests was 95% using a cutoff value ≥1 ISU/l with poor corresponding sensitivity values (58% for Ara h 2, 62% for Ara h 6), but good specificity values (95% for both tests). In conclusion, the diagnostic value of sIgE to Ara h 6 on population level was as good as sIgE to Ara h 2. On individual level, however, 5% of the subjects showed contradicting results between both tests using a cutoff of 0.3 ISU/l, leading to a risk of misdiagnosis if only one of both tests is used.
机译：针对Ara h 2的特异性IgE（sIgE）可用于诊断花生过敏。我们的目的是评估sIgE对另一种2S白蛋白Ara h 6的诊断价值，该人群被怀疑患有花生过敏。如果对花生进行了诊断性双盲，安慰剂对照食物激发试验，则包括2002年至2013年间怀疑患有花生过敏的受试者。通过ImmunoCAP ISAC 112测量到Ara h 2和Ara h 6的sIgE。在107名受攻击的受试者中，有65名具有阳性挑战（61％）。 sIgE对Ara h 2和Ara h 6的判别能力相当：AUC为0.81对0.82。两种测试的阳性预测值为95％，使用临界值≥1ISU / l，相应的敏感度值较差（Ara h 2为58％，Ara h 6为62％），但特异性值较高（两种测试均为95％） 。总之，sIgE对Ara h 6的诊断价值与sIgE对Ara h 2的诊断价值一样。但是，在个体水平上，有5％的受试者在两次测试之间显示出相矛盾的结果，临界值为0.3 ISU / l ，如果仅使用这两种测试中的一种，则会导致误诊的风险。

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