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首页> 外文期刊>Allergy >Natural rubber latex and chestnut allergy: cross-reactivity or co-sensitization?
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Natural rubber latex and chestnut allergy: cross-reactivity or co-sensitization?

机译：天然橡胶乳胶和板栗过敏：交叉反应或共敏化？

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BACKGROUND: Chestnut and natural rubber latex (NRL) allergy are often associated in the latex-fruit syndrome. AIM OF THE STUDY: To establish whether the concurrent NRL and chestnut IgE antibody reactivity are the results of co-sensitization or cross-reactivity. METHODS: Sera from 19 patients with chestnut- and NRL-specific IgE were selected and tested for reactivity with recombinant (r) latex allergens. Cross-reactivity was explored by IgE-inhibition experiments using chestnut or NRL allergens as solid phase on ImmunoCAP. RESULTS: IgE-antibodies were detected to rHev b 6.01 (prohevein) in 58% of the sera, to rHev b 5 in 32%, to rHev b 12 in four of 13 sera, to rHev b 7.02 and rHev b 11 in four, and to rHev b 1 in two of 19 sera. rHev b 8-IgE antibodies were found in nine sera (47%), whereas six displayed mono-sensitization to rHev b 8 with regard to our test panel. Three of 16 sera showed IgE to cross-reactive carbohydrate determinants. In most sera recognizing rHev b 5 and/or rHev b 6.01 as major allergens the IgE-reactivity to NRL remained unaffected by chestnut extract and chestnut-IgE remained unaffected by NRL extract. Conversely, in sera with rHev b 8 as dominant allergen IgE-binding to NRL was nearly completely inhibited by chestnut and vice versa. IgE-binding to rHev b 8 was abolished by chestnut extract. CONCLUSIONS: Although patients have concomitant IgE antibody reactivity to chestnut and NRL, cross-reactivity could be demonstrated mainly in those patients with IgE to Hev b 8 (profilin) from NRL.
机译：背景：栗子和天然橡胶乳胶（NRL）过敏通常与乳胶水果综合征相关。研究目的：建立同时的NRL和栗IgE抗体反应性是共敏化还是交叉反应性的结果。方法：选择来自19位栗子和NRL特异性IgE患者的血清，并测试其与重组（r）乳胶过敏原的反应性。通过将板栗或NRL过敏原作为固相在ImmunoCAP上进行IgE抑制实验，探索了交叉反应性。结果：在58％的血清中检测到rHev b 6.01（前体素）的IgE抗体，在13％的血清中检测到rHev b 5的占32％，在四个血清中检测到rHev b 12，在四个血清中检测到rHev b 7.02和rHev b 11，并在19份血清中有2份归入rHev b 1。 rHev b 8-IgE抗体在9个血清中发现（47％），而就我们的测试小组而言，有6个显示出对rHev b 8的单敏性。 16个血清中有3个显示IgE与交叉反应性碳水化合物决定簇有关。在大多数将rHev b 5和/或rHev b 6.01识别为主要过敏原的血清中，板栗提取物对NRL的IgE反应性保持不变，而NRL提取物对板栗IgE的反应保持不变。相反，在以rHev b 8为主要变应原的血清中，板栗几乎完全抑制了IgE与NRL的结合，反之亦然。栗提取物消除了与rHev b 8的IgE结合。结论：尽管患者对栗子和NRL具有伴随的IgE抗体反应性，但主要在那些对NRL的Hev b 8（profilin）具有IgE的患者中表现出交叉反应性。

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