...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Allergy >Detection of nickel and palladium contact hypersensitivity by a flow cytometric lymphocyte proliferation test
【24h】

Detection of nickel and palladium contact hypersensitivity by a flow cytometric lymphocyte proliferation test

机译：通过流式细胞仪淋巴细胞增殖试验检测镍和钯接触超敏反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We established a flow cytometric lymphocyte proliferation test (LPT) for the detection of nickel (Ni) and palladium (Pd) sensitization. Eighty-one consecutive patients with an indication for patch test (PT) were tested by LPT with Ni (NiSO4) and Pd (Na2PdCl4 and PdCl2) salts. The imprecision of the LPT was low (coefficient of variation 7.2%). Using PT as a diagnostic reference, the sensitivity and specificity of LPT were 74.4% and 80% for NiSO4, 74.4% and 78.3% for Na2PdCl4, and 57.2% and 85.4% for PdCl2, respectively. For both Ni and Pd, the likelihood ratio for a positive PT markedly increased with increasing LPT value. With medical history as a reference, the sensitivity and specificity were 40.6% and 82.1% for LPT and 59.4% and 89.7% for PT, respectively. Combination of LPT and PT resulted in a higher specificity of 95%, albeit lower sensitivity of 34.4%. In conclusion, flow cytometric LPT represents a reliable and useful method for the detection of Ni and Pd sensitization. LPT values correlate with PT results and, when used in combination with PT, increase test specificity.
机译：我们建立了流式细胞术淋巴细胞增殖测试（LPT），用于检测镍（Ni）和钯（Pd）致敏性。 LPT用镍（NiSO4）和Pd（Na2PdCl4和PdCl2）盐对LPT连续检查了八十一名有斑贴试验（PT）指征的患者。 LPT的不精确度很低（变异系数为7.2％）。使用PT作为诊断参考，LPT对NiSO4的敏感性和特异性分别为74.4％和80％，对Na2PdCl4分别为74.4％和78.3％，对PdCl2为57.2％和85.4％。对于Ni和Pd，正PT的似然比随着LPT值的增加而显着增加。以病史为参考，LPT的敏感性和特异性分别为40.6％和82.1％，PT的敏感性和特异性分别为59.4％和89.7％。 LPT和PT的组合可产生95％的较高特异性，尽管敏感性较低，为34.4％。总之，流式细胞仪LPT代表了一种可靠且有用的检测Ni和Pd致敏的方法。 LPT值与PT结果相关，当与PT结合使用时，可提高测试特异性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号