The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

Apostolovic D.; Sanchez-Vidaurre S.; Waden K.; Curin M.; Grundstrom J.; Gafvelin G.; Velickovic T. Cirkovic; Gronlund H.; Thomas W. R.; Valenta R.; Hamsten C.; van Hage M.

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The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

机译：猫lipocalin Fel d 7及其与狗lipocalin Can f 1的交叉反应

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We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.

机译：我们调查了140位猫敏感的瑞典患者中对猫脂钙素Fel d 7致敏的患病率，并阐明了其与狗脂钙素Can f 1的变应原活性和交叉反应性。140例患者中有65人对rFel d 7有IgE。 60也有IgE到rCan f1。发现IgE水平与rFel d 7和rCan f 1之间存在适度相关性。 rFel d 7在体外激活了嗜碱性粒细胞，并在13名患者中的4名患者中抑制了IgE与rCan f 1的结合，而rCan f 1在13名患者中的7名中抑制了IgE与rFel d 7的结合。 Fel d 7和Can f 1在蛋白质结构上显示出高度相似性，并且使用交叉反应抗血清发现了共同的表位。 Fel d 7是瑞典猫敏感人群中常见的过敏原，可与Can f 1交叉反应，并且可能对猫（但对狗过敏）患者产生症状。

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来源
《Allergy》 |2016年第10期|共6页
作者
Apostolovic D.; Sanchez-Vidaurre S.; Waden K.; Curin M.; Grundstrom J.; Gafvelin G.; Velickovic T. Cirkovic; Gronlund H.; Thomas W. R.; Valenta R.; Hamsten C.; van Hage M.;
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正文语种 eng
中图分类医学免疫学;
关键词
Can f 1; cat allergy; cross-reactivity; dog allergy; Fel d 7;

机译：可以f 1;猫过敏;交叉反应;狗过敏;Fel d 7;

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4. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1 [J] . Apostolovic D., Sanchez-Vidaurre S., Waden K., Allergy . 2016,第10期

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The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

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