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首页> 外文期刊>Allergy >Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms
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Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms

机译：与消化系统症状相关的肥大细胞增多症中色氨酸减少和犬尿氨酸水平升高

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The main metabolism pathway of tryptophan is protein formation, but it can also be metabolized into serotonin and kynurenine. Indoleamine 2,3-dioxygenase (IDO) is the enzyme that catalyzes the degradation of tryptophan into kynurenine. Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in various tissues with 57% of patients having gastrointestinal involvement. We studied tryptophan metabolism in mastocytosis patients displaying or not gastrointestinal features and healthy subjects (n = 26 in each group). Mastocytosis patients with digestive symptoms displayed significantly increased kynurenine level and IDO activity as compared to healthy controls and mastocytosis patients without digestive symptoms. This could be linked to mast cell-mediated digestive inflammation among patients with mastocytosis. This work is the first focusing on kynurenine pathway in a mast cell disease and could help to understand the pathogenesis of digestive features in mastocytosis as well as in other mast cell-mediated diseases.
机译：色氨酸的主要代谢途径是蛋白质形成，但也可以代谢成5-羟色胺和犬尿氨酸。吲哚胺2，3-二加氧酶（IDO）是催化色氨酸降解为犬尿氨酸的酶。肥大细胞增多症是一种异质性疾病，其特征是肥大细胞在各种组织中蓄积，其中57％的患者患有胃肠道疾病。我们研究了显示或不显示胃肠功能的肥大细胞增多症患者和健康受试者的色氨酸代谢（每组n = 26）。与健康对照组和无消化系统症状的肥大细胞增多症患者相比，具有消化系统症状的肥大细胞增多症患者显示犬尿氨酸水平和IDO活性显着增加。这可能与肥大细胞增多症患者中肥大细胞介导的消化道炎症有关。这项工作是第一个针对肥大细胞疾病中犬尿氨酸途径的研究，可以帮助了解肥大细胞增多症以及其他肥大细胞介导的疾病中消化功能的发病机理。

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