Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma

Song J. -S.; You J. -S.; Jeong S. -I.; Yang S.; Hwang I. -T.; Im Y. -G.; Baek H. -S.; Kim H. -Y.; Suh D. -I.; Lee H. -B.; Izuhara K.

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Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma

机译：哮喘儿童血清骨膜素水平与气道对乙酰甲胆碱和甘露醇的高反应性相关

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BackgroundPeriostin is a matricellular protein, and its synthesis in airway epithelial cells and lung fibroblasts is induced by interleukin (IL)-4 and IL-13. The significance of periostin as a biomarker of T(H)2-induced airway inflammation, and (importantly) as a measure of the response to T(H)2-targeted therapy, has recently been emphasized. We explored the relationship between periostin and airway hyperresponsiveness (AHR) in asthmatic children.

机译：背景骨膜素是一种基质细胞蛋白，其在气道上皮细胞和肺成纤维细胞中的合成是由白介素（IL）-4和IL-13诱导的。最近已强调了骨膜素作为T（H）2诱导的气道炎症的生物标志物的重要性，以及（重要的）作为对T（H）2靶向治疗反应的一种度量。我们探讨了哮喘儿童的骨膜素与气道高反应性（AHR）之间的关系。

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《Allergy》 |2015年第6期|共8页
作者
Song J. -S.; You J. -S.; Jeong S. -I.; Yang S.; Hwang I. -T.; Im Y. -G.; Baek H. -S.; Kim H. -Y.; Suh D. -I.; Lee H. -B.; Izuhara K.;
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正文语种 eng
中图分类医学免疫学;
关键词
airway hyperresponsiveness; asthma; children; periostin;

机译：气道反应过度;哮喘;儿童;骨膜素;

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1. Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma [J] . Song J. -S., You J. -S., Jeong S. -I., Allergy . 2015,第6期

机译：哮喘儿童血清骨膜素水平与气道对乙酰甲胆碱和甘露醇的高反应性相关
2. Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide in children with asthma [J] . Park Young A., Park Hyun Bin, Kim Yoon Hee, The journal of asthma . 2017,第6期

机译：哮喘儿童的甘露冬季和甲素和甲素和氧化碳含量的气道高反应性
3. Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics [J] . Takahashi Kentaro, Meguro Kazuyuki, Kawashima Hirotoshi, The journal of asthma . 2019,第3期

机译：血清骨蛋白水平用作嗜酸性气道炎症和固定气流限制在良好控制的哮喘中的生物标志物
4. Sputum Eosinophil Counts and Eosinophil Cationic Protein (ECP) Levels in Cough-Variant Asthma and in Classic Asthma, and Their Relationships to Airway Hypersensitivity or Maximal Airway Response to Methacholine [C] . Young Yoo, Young Yull Koh, Hee Kang Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：痰嗜酸性粒细胞计数和嗜酸铈粒细胞阳离子蛋白（ECP）水平在咳嗽变异哮喘和经典的哮喘，以及它们与气道超敏反应或最大气道对甲磺酸的关系的关系
5. Sedated Versus Non-Sedated Methacholine Challenge for the Diagnosis of Airway Hyper-Responsiveness in Horses [D] . Lack, Amy Catherine. 2019

机译：镇静与非镇静的甲咯素挑战，用于诊断马匹的气道超响应性
6. Serum levels of periostin and exercise-induced bronchoconstriction in asthmatic children [O] . Ju Hwan Cho, Kyubo Kim, Jung Won Yoon, 2019

机译：哮喘儿童的血清骨膜素水平和运动引起的支气管收缩
7. Association of serum periostin levels with clinical features in children with asthma [O] . Süleyman Tolga Yavuz, Soyhan Bagci, Ahmet Bolat, 2021

机译：血清骨膜素水平与哮喘儿童临床特征的关联

Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma

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