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Immunogenicity of trivalent-inactivated influenza vaccine among children less than 4 years old

机译：小于4岁以下儿童的三价灭活流感疫苗的免疫原性

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摘要

We studied the immunogenicity of trivalent-inactivated influenza vaccine. Subjects were 259 children under 4 years old who visited six pediatric clinics to undergo influenza vaccination. Age distribution was 64 aged <1.0, 65 aged 1.0-1.9, 64 aged 2.0-2.9, and 66 aged 3.0-3.9 years, including subjects who had been previously vaccinated within the last three years, 0% (0/64) aged <1.0, 26% (17/65) aged 1.0-1.9, 72% (46/64) aged 2.0-2.9, and 77% (51/66) aged 3.0-3.9 years old. Two doses of vaccine were given subcutaneously four weeks apart. Dosage was 0.l mL for children under 1 year old, while for children aged one year or older, dosage was 0.2mL, based on standard Japanese recommendations. To measure hemagglutination inhibition (HI) antibody titer, triplet sera were obtained before vaccination (S0), 4 weeks after the first vaccination (S1), and 4 weeks after the second vaccination (S2). The geometric mean of HI antibody titer, the response proportion (titer rise > or =4-fold), and the achievement proportion (postvaccination titer > or =1 : 40) were calculated by age group. Analysis of variance was used to estimate the independent effect of age and prevaccination titer on antibody increase. The geometric means of HI antibody titer were lower among the two younger age groups than among the two older age groups, regardless of vaccine strain or when blood samples were collected. The achievement proportion after 2 doses of vaccine in the <1.0, 1.0-1.9, 2.0-2.9, 3.0-3.9 year age groups were 38%, 58%, 89%, and 85% against A (HI) ; 52%, 54%, 81%, and 73% against A (H3) ; and 23%, 49%, 67%, and 71% against B. Regarding the analysis of variance, prevaccination titer consistently indicated strong effects on antibody increase, regardless of vaccine strain or combination of paired sera. After two doses of vaccine (S2/S0), significant effects of age on antibody induction were shown against A (H1) and B (p = 0.000 and 0.002). Thus, the immunogenicity of trivalent-inactivated influenza vaccine was strongly influencedby prevaccination titer and age. Even two doses of vaccine did not induce a protective antibody level in about 50 to 80% of subjects among infants aged <1.0 year, and 40 to 50% among children 1.0-1.9 year old. Infectious Diseases
机译：我们研究了三价灭活流感疫苗的免疫原性。 4岁以下的受试者是259名儿童，他访问了六个儿科诊所以进行流感疫苗接种。年龄分布为64岁，年龄<0-1.9岁，64岁，65岁，66岁，66岁，66岁，包括预先在过去三年内接种疫苗的受试者，0％（0/64）< 1.0,26％（17/65）1.0-1.9，72％（46/64），年龄为2.0-2.9岁，77％（51/66），年龄在3.0-3.9岁。将两种剂量的疫苗皮下注射四周。 1岁以下儿童的剂量为0.L mL，而对于一年或以上的儿童，剂量为0.2ml，基于标准日本建议。为了测量血凝集抑制（HI）抗体滴度，在第一次接种疫苗接种后4周（S1）的接种疫苗（S0）之前获得三重素血清，并在第二次接种后4周（S2）。高抗体滴度的几何平均值，响应比例（滴度>或= 4倍），以及通过年龄组计算的成就比例（Postvaccation Titer> Or = 1：40）。方差分析用于估计年龄和预处理滴度对抗体增加的独立效应。在两个较小的年龄组中，HI抗体滴度的几何手段比两个较大的年龄组中，无论疫苗菌株还是收集血液样品。在<1.0,1.0-1.9,3.0-2.9，3.0-3.9年龄组的2剂疫苗后的成就比例为38％，58％，89％和85％（嗨）; 52％，54％，81％和73％（H3）;对于方差分析，23％，49％，67％和71％，预防滴度始终如一地表明了对抗体的强烈影响，无论疫苗菌株还是配对血清的组合。经过两剂疫苗（S2 / S0）后，针对（H1）和B（P = 0.000和0.002）显示年龄对抗体诱导的显着效果。因此，三价灭活的流感疫苗的免疫原性受到预防滴度和年龄的强烈影响。甚至两剂疫苗都没有诱导约50％至80％的婴儿婴儿的保护抗体水平<1.0岁的婴儿，40-1.9岁儿童中的40％至50％。传染性疾病

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  • 来源
    《感染症学雑誌》 |2007年第3期|共7页
  • 作者

    Irie S; Fujieda M; Ito K; Ishibashi M; Takamizawa T; Ishikawa T; Takasaki Y; Shindo S; Yokoyama T; Yamashita Y; Shibao K; Koyanagi H; Maeda A; Hirota Y;

  • 作者单位

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

    Department of Surgery The University of Texas Medical Branch 301 University Boulevard Galveston Texas 77555;

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  • 原文格式 PDF
  • 正文语种 jpn
  • 中图分类 内科学;
  • 关键词

    Influenza Vaccines;

    机译：流感疫苗;

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