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首页> 外文期刊>感染症学雑誌 >Three sisters of pulmonary Mycobacterium avium complex disease
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Three sisters of pulmonary Mycobacterium avium complex disease

机译：肺组分抗原血栓疾病的三个姐妹

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We reported three sisters of pulmonary Mycobacterium avium complex (MAC) disease. The oldest sister was complaining of bloody sputum, and cultures were positive for M. avium. By monotherapy with clarithromycin, symptom and imaging findings had shown no progression for six years. The second sister was complaining of productive cough, and cultures were positive for M. intracellulare. Her symptom and imaging findings had shown no progression for seven years without any treatment. The third sister had rheumatoid arthritis and diabetes mellitus, and cultures were positive for M. intracellulare. Although she received chemotherapy with rifampicin, clarithromycin, ethambutol, and kanamycin, symptom and imaging findings had progressed gradually. She died of respiratory failure four years later. Autopsy findings revealed no disseminated MAC disease. The results which three cases showed different isolate patterns and clinical courses suggest the importance of underlying anti-mycobacterial immunological impairmentand defects of local host defense rather than virulence of infected strains as the pathogenesis of pulmonary MAC disease.
机译：我们报道了三个肺组分抗钙杂交综合体（Mac）疾病的姐妹。最古老的妹妹抱怨血痰，培养为禽兽阳性。通过用克拉霉素的单疗法，症状和成像发现显示出六年的进展。第二个姐姐抱怨生产咳嗽，培养物对M.细胞内呈阳性。她的症状和成像结果显示出七年没有任何治疗的进展。第三个姐姐有类风湿性关节炎和糖尿病，培养物对M.细胞内呈阳性。虽然她接受了利福平，克拉霉素，乙胺醇和卡那霉素的化疗，但症状和成像结果逐渐进展。四年后她死于呼吸失败。尸检发现没有易溶的MAC病。三种病例显示出不同的孤立模式和临床课程表明潜在的抗分法免疫障碍和局部宿主防御缺陷的重要性，而不是感染菌株的毒力作为肺癌疾病的发病机制。

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