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首页> 外文期刊>感染症学雑誌 >Varicella-zoster virus symptoms and polyneuropathy in a patient with human immunodeficiency virus infection not improved until highly active anti-retroviral therapy added to acyclovir therapy
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Varicella-zoster virus symptoms and polyneuropathy in a patient with human immunodeficiency virus infection not improved until highly active anti-retroviral therapy added to acyclovir therapy

机译：患有人免疫缺陷病毒感染的患者中的Varicella-Zoster病毒症状和多变病变，直到加入到Acyclovir治疗中的高度活跃的抗逆转录病毒治疗

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In March 2003, a 34-year-old man with left facial palsy, dysphagia, and hoarseness treated with acyclovir suffered worsened dermatological and neurological problems. A routine blood test in early April showed the patient to be HIV-antibody positive, so he was transferred to our hospital. Blood analysis showed serum HIV-RNA at 96,000 copies/mL and a CD 4 count of 170/microL. Brain MRI taken on admission showed a T 2 high lesion in their left medulla. Acyclovir was thought to be ineffective due to reduced cell-mediated immunity because of the HIV infection, and HAART therapy was begun. After two months of HAART, skin lesions and the T 2 high lesion in left medulla improred. HIV-RNA became undetectable and the CD 4 count exceeded 500/microL. Intracellular cytokine analysis by flow cytometry showed a shift from Th 2 to Th 1 dominance. The elimination of VZV may thus have been promoted by the combination of acyclovir and HAART.
机译：2003年3月，一个34岁的男子患有左侧面部麻痹，吞咽困难和随着Acyclovir治疗的嘶哑遭受恶劣的皮肤病和神经系统问题。 4月初的常规血液测试显示患者是HIV-抗体阳性，所以他被转移到我们的医院。 血液分析显示血清HIV-RNA，96,000拷贝/ mL和CD 4计数为170 / micro。 在入院的脑部MRI表现出左侧髓质的T 2高病灶。 由于HIV感染，由于细胞介导的免疫力降低，Acyclovir被认为是无效的，并且开始了Haart治疗。 经过两个月的HAART，皮肤病变和左髓质的T 2高病灶令人克。 HIV-RNA变得不可检测，CD 4计数超过500 / micro。 流式细胞仪的细胞内细胞因子分析显示从2至Th 1的偏移。 因此，可以通过Acyclovir和Haart的组合促进VZV的消除。

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