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首页> 外文期刊>感染症学雑誌 >Resistance to antimicrobiotics and mutation of PBPs in Streptococcus pneumoniae isolated from Kinki region of Japan
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Resistance to antimicrobiotics and mutation of PBPs in Streptococcus pneumoniae isolated from Kinki region of Japan

机译：日本Kinki地区中分离出肺炎链球菌肺炎链球菌抗菌病和Pbps突变的抗性

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We studied the susceptibility to penicillin G (PCG) and other antimicrobiotics in 235 clinical isolates of Streptococcus pneumoniae. Samples were collected between April 1 and June 30, 2000 from nine medical institutions of the Kinki Region of Japan. We classified the minimum inhibitory concentration (MIC) of PCG according to the National Committee for Clinical Laboratory Standards (NCCLS) criteria. The overall rate of all types of S. pneumoniae resistance was 53.2% (penicillin-susceptible S. pneumoniae (PSSP): 46.8%, penicillin-intermediate S. pneumoniae (PISP): 42.6%, penicillin-resistant S. pneumoniae (PRSP): 10.6%). In other antimicrobiotics, the resistance (R)/intermediate susceptibility (I) rates (R/I%) were as follows: ceftriaxone, 28.9%; cefotaxime, 7.7%; imipenem, 8.9%; meropenem, 9.8%; clarithromycin, 82.6%; clindamycin, 42.1%; levofloxacin, 0.4%; vancomycin, 0%. We used the polymerase chain reaction to study the mutations of the penicillin-binding proteins pbp1 a, pbp2b, and pbp2x in 140 strains of S. pneumoniae in the MIC for PCG was < 0.5 microgram/ml. Among the 109 strains of PSSP, 32 (29.4%) had no mutation and 77 (70.6%) showed mutation of more than one of the pbp mutations. Among the 31 strains of PISP, only 1 strain (3.2%) was not mutated. Since 70.6% of the strains classified as PSSP had pbp mutations, S. pneumoniae clearly can acquire resistance to anti-microbiotics. In the future, a comprehensive surveillance of S. pneumoniae is necessary.
机译：我们研究了对135例肺炎链球菌临床分离株的青霉素G（PCG）和其他抗菌生物学的敏感性。 2000年4月1日至6月30日之间收集了样品，来自日本的Kinki地区的九个医疗机构。根据国家临床实验室标准（NCCLS）标准，我们根据国家委员会分类了PCG的最小抑制浓度（MIC）。所有类型的S.肺炎抵抗力的总体率为53.2％（青霉素 - 易感S.肺炎（PSSP）：46.8％，青霉素中级S.肺炎（PISP）：42.6％，青霉素抗性S.肺炎（PRSP） ：10.6％）。在其他抗菌生物学中，抗性（R）/中间敏感性（I）率（r / i％）如下：头孢曲松，28.9％;头孢噻肟，7.7％; Imipenem，8.9％;梅洛宁，9.8％;克拉霉素，82.6％; Clindamycin，42.1％;左氧氟沙星，0.4％;万古霉素，0％。我们利用聚合酶链反应研究青霉素结合蛋白PBP1a，PBP2b和PBP2X的突变在PCG的MIC中的140株S.肺炎的肺炎群中的<0.5微克/ ml。在109个PSSP菌株中，32个（29.4％）没有突变，77（70.6％）显示出多种PBP突变的突变。在31个PISP菌株中，仅突变1株（3.2％）。由于70.6％的菌株被归类为PSSP具有PBP突变，S.肺炎显然可以获得抗微生物的抵抗力。将来，必须全面监测肺炎。

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