• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>感染症学雑誌 >Local reactions after diphtheria-tetanus-acellular pertussis vaccines in mice; changes in histopathology at the injection site
【24h】

Local reactions after diphtheria-tetanus-acellular pertussis vaccines in mice; changes in histopathology at the injection site

机译：小鼠白喉 - 破伤风 - 细胞植物疫苗后局部反应; 注射部位组织病理学的变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diphtheria-tetanus-acellular pertussis vaccine (DTaP) developed in Japan is now widely used worldwide. DTaP is safer than the diphtheria-tetanus-whole-cell pertussis vaccine (DTwP) and has fewer severe side effects, but local reactions such as redness, swelling, and induration are still reported. The pathophysiological mechanism of these reactions is controversial. To clarify the cause of local reactions, we conducted studies using the mouse model. After administering either one or two abdominal subcutaneous DTaP inoculations, we observed changes in histopathology at the injection site at 24h, 48h, and 7 days. The control group, inoculated with physiologic saline, showed no significant changes either pathologically or with the naked eye. All mice after DTaP vaccination showed indurations at the injection site. Pathologically, we watched leukocyte invasion into or around the site, especially neutrophils and eosinophils. After the first vaccination, the extent of the invasion was strong 24h and 7 days later. At 24h following the second vaccination, a dramatic leukocyte invasion seen persisted at 7days. At 7 days after the first vaccination, peripheral fibrosis had begun, and when a second vaccination was administered, it began even earlier at the second site. These histopathological changes show that local reactions are caused by both inflammatory and allergic responses. Because this mouse study resulted in the same pattern of reactions observed in humans, this method will be useful for studies focusing on local reactions.
机译：在日本开发的白喉 - 破伤风 - 植物疫苗疫苗（DTAP）现在广泛应用于全球。 DTAP比Diphtheria-Tetanus-全细胞植物疫苗（DTWP）更安全，并且仍然报告了较严重的副作用，但局部反应仍然仍然报告。这些反应的病理生理机制是有争议的。为了澄清局部反应的原因，我们使用小鼠模型进行了研究。在施用一个或两个腹部皮下DTAP接种后，我们观察到注射部位在24h，48h和7天内的组织病理学的变化。用生理盐水接种的对照组显示出病理或肉眼无明显变化。 DTAP疫苗接种后的所有小鼠显示注射部位的诱导。病理上，我们观看了白细胞侵袭了网站，尤其是中性粒细胞和嗜酸性粒细胞。在第一次疫苗接种后，侵袭程度强劲24小时和7天。在第二次疫苗接种后24小时，在7天持续存在的戏剧性白细胞侵袭。在第一次疫苗接种后7天，已经开始，外周纤维化，并且当施用第二次疫苗接种时，它甚至在第二个地点之前开始。这些组织病理学变化表明，局部反应是由炎症和过敏反应引起的。因为这种鼠标研究导致人体中观察到的相同模式，所以该方法可用于关注局部反应的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号