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procedure for the cultivation of bordetella pertussis, pertussis toxoid, and pertussis vaccines and procedure for the production of pertussis vaccines
procedure for the cultivation of bordetella pertussis, pertussis toxoid, and pertussis vaccines and procedure for the production of pertussis vaccines
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机译：百日咳杆菌，百日咳类毒素和百日咳疫苗的培养程序以及百日咳疫苗的生产程序
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摘要
There is disclosed a method for culturing Bordetella Pertussis in the presence of a cellulose and/or cellulose derivatives. The present method is useful for obtaining a mixed antigen comprising pertussis toxin and filamentous hemagglutinin in a large amount at low cost. From the antigen, there can be obtained a stable and effective pertussis toxoid to be used for a pertussis vaccine. There is also disclosed a vaccine comprising the pertussis toxoid as an active ingredient and a gelatin and/or gelatin derivatives as a stabilizing agent. The present vaccine is extremely stable and can be stored for a prolonged period of time.
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