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首页> 外文期刊>感染症学雑誌 >A nosocomial outbreak of diarrhea caused by toxin A-negative, toxin B-positive Clostridium difficile in a cancer center hospital
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A nosocomial outbreak of diarrhea caused by toxin A-negative, toxin B-positive Clostridium difficile in a cancer center hospital

机译：在癌症中心医院中毒素A阴性，毒素B阳性梭菌腹菌瘤引起的腹泻的医院爆发

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Between February and July 2001, 15 patients were diagnosed as Clostridium difficile-associated diarrhea in a ward of hematological neoplasm and lung cancer in a cancer center hospital. Of these 15 patients, 10 had malignant lymphoma, and 12 and 11 had exposure to antimicrobial agents and cancer chemotherapy, respectively, before the onset of diarrhea. Toxin A-positive, toxin B-positive (A+ B+) C. difficile was recovered from five patients and the remaining 10 patients suffered from diarrhea caused by toxin A-negative, toxin B-positive (A- B+) strains. All of the 10A- B+ isolates represented an identical banding pattern by PCR ribotyping and classified into one type (two subtypes) by pulsed field gel electrophoresis typing, indicating that a nosocomial outbreak of diarrhea caused by A- B+ C. difficile occurred among the patients hospitalized on this ward. Detection of toxin A in stool specimens by a toxin A detection kit was performed on 14 patients. Although two patients who carried A+ B+ strains were positive for toxin A assay, toxin A detection test was negative in 12 patients including 10 patients with A- B+ C. difficile infection. Diagnosis of C. difficile-associated diarrhea by combination of toxin A assay in feces and culture of C. difficile could successfully lead to recognition of an outbreak caused by A- B+ C. difficile in a cancer center hospital.
机译：2001年2月至7月，15名患者被诊断为在癌症中心医院的血液肿瘤和肺癌病房中被诊断为Clostridium艰难的腹泻。在这15名患者中，10例具有恶性淋巴瘤，12和11分别在腹泻发作之前分别接触抗菌药物和癌症化疗。从五名患者中回收毒素A阳性，毒素B阳性（A + B +）C.艰难梭菌，剩余的10名患者患有由毒素A阴性，毒素B阳性（A-B +）菌株引起的腹泻。所有10A-B +分离物通过PCR核糖型表示相同的条带图案，并通过脉冲场凝胶电泳打字分类为一种（两种亚型），表明患者中发生了由A-B + C.艰难梭菌引起的腹泻的医院爆发住在这个病房里。通过毒素检测毒素标本中的毒素A检测试剂盒进行检测试剂盒进行了14名患者。虽然携带+ B +菌株的两名患者对于毒素进行阳性，但在12名患者中，毒素的检测试验是阴性的，其中10名A-B + C.艰难梭菌感染患者。通过组合毒素A型腹膜瘤和培养物组合诊断C.艰难梭菌的诊断能够成功地识别癌症中心医院中A-B + C艰难梭菌引起的爆发。

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