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The trend of childhood bacterial meningitis in Japan (2000-2002)

机译：日本儿童细菌脑膜炎的趋势（2000-2002）

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摘要

We surveyed the epidemiology of bacterial meningitis in pediatrics between July 2000 and December 2002 in Japan and obtained the following results.: The number of cases of bacterial meningitis was 316 (182 boys and 134 girls), which was equivalent to 1.1-1.7 children out of 1,000 hospitalized those in pediatrics per year. The age-distribution for the infections was the highest under 1 year of age and it decreased as the age increased. Haemophilus influenzae was the most common pathogen causing the infections, followed by Streptococcus pneumoniae, group B streptococcus, and Escherichia coli. Relationship between causing pathogens and age-distribution was as follows: group B streptococcus and E. coli were major pathogens under 4 months of age and H. influenzae and S. pneumoniae were major pathogens over 4 months of age. Susceptibility tests performed at each facility demonstrated that 53.7% of H. influenzae isolates and 67.7% of S. pneumoniae isolates in 2003 were drug-resistant. As ampicillin and cephem antibiotics are effective against GBS, E. coli and Listeria at present, then the combination of ampicillin and cephem antibiotics was used as first line antibiotics in many facilities under 4 month of age and a combination of carbapenem which showed effective against PRSP and cephem which showed effective against H. influenzae is first choice against childhood bacterial meningitis over 4 month of age.
机译：我们调查了2000年7月和2002年12月在日本的儿科细胞脑膜炎的流行病学，并获得了以下结果：细菌脑膜炎病例数是316（182名男孩和134名女孩），相当于1.1-1.7个儿童每年1,000人住院儿科学院。感染的年龄分布是1岁以下的最高，随着年龄的增加而下降。嗜血杆菌嗜血杆菌是导致感染的最常见的病原体，其次是链球菌肺炎料，B组链球菌和大肠杆菌。导致病原体和年龄分布之间的关系如下：B组链球菌和大肠杆菌是4个月的主要病原体，H.Compenenzae和S.肺炎是4个月的主要病原体。在每个设施中进行的易感性试验表明，53.7％的H型流感分离株和2003年的肺炎肺炎群分离物的67.7％是耐药性。随着氨苄青霉素和Cephem抗生素目前对GBS有效，随着GBS，大肠杆菌和李斯特潜力，那么氨苄青霉素和Cephem抗生素的组合在4个月的4个月内的许多设施中使用了第一线抗生素，并且表现出对PRSP有效的CarbapeNem的组合和Cephem表现出对H流感效果有效的是4个月的儿童细菌脑膜炎的首选。

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