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首页> 外文期刊>Allergy >Anaphylaxis to diclofenac: Nine cases reported to the Allergy Vigilance Network in France
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Anaphylaxis to diclofenac: Nine cases reported to the Allergy Vigilance Network in France

机译：双氯芬酸的过敏反应：法国过敏警戒网报告了9例

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摘要

Nine cases of diclofenac hypersensitivity recorded by the Allergy Vigilance Network in France from 2002 to 2012 were studied. Data from history, symptoms, skin tests, basophil activation tests, and oral challenge (OC) were recorded. Grade 3 severe anaphylactic reactions occurred in seven cases of nine. IgE-dependent anaphylaxis was confirmed in six cases: positive intradermal tests (n = 4), a syndromic reaction during skin tests (n = 1), and one case with grade 1 reaction and negative skin tests had an anaphylactic shock to the OC. A nonimmune reaction was suspected in one case. An IgE-dependent mechanism may be the predominant cause of adverse reactions to diclofenac. Allergy skin tests must be carried out sequentially at the recommended concentrations. BATs may be helpful because they can support the diagnosis of anaphylaxis. Given the risks of a direct challenge to diclofenac, OC to aspirin should be performed first to exclude a nonimmunologic hypersensitivity to NSAIDs. Tests for specific IgEs to most frequently used NSAIDs such as diclofenac and ibuprofen are urgently needed.
机译：研究了2002年至2012年法国过敏警戒网记录的9例双氯芬酸超敏反应病例。记录病史，症状，皮肤测试，嗜碱性粒细胞活化测试和口服攻击（OC）的数据。 7例（共9例）发生3级严重过敏反应。 IgE依赖性过敏反应已确认为六例：皮内试验阳性（n = 4），皮肤试验期间的综合症状（n = 1），以及1级反应和皮肤试验阴性的一例对OC产生了过敏性休克。怀疑有一种非免疫反应。 IgE依赖性机制可能是双氯芬酸不良反应的主要原因。过敏性皮肤测试必须按推荐浓度顺序进行。 BAT可能会有所帮助，因为它们可以支持过敏性反应的诊断。考虑到直接挑战双氯芬酸的风险，应首先进行阿司匹林的OC排除对NSAIDs的非免疫性超敏反应。迫切需要针对最常用的NSAID（例如双氯芬酸和布洛芬）进行特定IgE的测试。

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