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First European data from the network of severe allergic reactions (NORA)

机译：来自严重过敏反应（NORA）网络的首批欧洲数据

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Methods: Tertiary allergy, dermatology and paediatric units in 10 European countries took part in this pilot phase of the first European Anaphylaxis Registry, from June 2011 to March 2014. An online questionnaire was used to collect data on severe allergic reactions based on the medical history and diagnostics.Results: Fifty-nine centres reported 3333 cases of anaphylaxis, with 26.7% below 18 years of age. Allergic reactions were mainly caused by food (children and adults 64.9% and 20.2%, respectively) and insect venom (20.2% and 48.2%) and less often by drugs (4.8% and 22.4%). Most reactions occurred within 30 min of exposure (80.5%); a delay of 4+ hours was mainly seen in drug anaphylaxis (6.7%). Symptom patterns differed by elicitor, with the skin being affected most often (84.1%). A previous, usually milder reaction to the same allergen was reported by 34.2%. The mainstay of first-line treatment by professionals included corticoids (60.4%) and antihistamines (52.8%). Only 13.7% of lay-or self-treated reactions to food and 27.6% of insect anaphylaxis received on-site adrenaline.Conclusion: This pilot phase of a pan-European registry for severe allergic reactions provides for the first time data on anaphylaxis throughout Europe, demonstrates its potential functionality and allows a comparison of symptom patterns, elicitors and treatment habits between referral centres and countries.Background: Occurrence, elicitors and treatment of severe allergic reactions are recognized and reported differently between countries. We aimed to collect standardized data throughout Europe on anaphylaxis referred for diagnosis and counselling.
机译：方法：2011年6月至2014年3月，来自10个欧洲国家的第三级过敏，皮肤病学和儿科部门参加了首个欧洲过敏反应注册中心的试验阶段。使用在线问卷收集了基于病史的严重过敏反应数据结果：59个中心报告了3333例过敏反应，其中18岁以下的占26.7％。过敏反应主要由食物（儿童和成人分别为64.9％和20.2％）和昆虫毒液（分别为20.2％和48.2％）和药物引起的（4.8％和22.4％）引起。大多数反应发生在暴露后30分钟内（80.5％）;延误4小时以上主要见于药物过敏反应（6.7％）。引发剂的症状模式有所不同，皮肤受影响最频繁（84.1％）。据报道，以前对同一过敏原的反应通常较温和，为34.2％。专业人士的一线治疗的主要对象包括皮质类固醇（60.4％）和抗组胺药（52.8％）。现场肾上腺素仅占食物的自发或自我治疗反应的13.7％和昆虫过敏反应的27.6％。结论：整个欧洲严重过敏反应注册表的试验阶段首次提供了整个欧洲的过敏反应数据展示了其潜在功能，并允许比较转诊中心与国家/地区之间的症状模式，诱发因素和治疗习惯。背景：严重过敏反应的发生，诱发因素和治疗在不同国家之间得到认可和报道。我们旨在收集整个欧洲用于诊断和咨询的过敏反应的标准化数据。

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