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首页> 外文期刊>日本耳鼻咽喉科学会会報 >Systemic effects of intranasal steroid drops in patients with dysosmia
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Systemic effects of intranasal steroid drops in patients with dysosmia

机译：患有疑难血患者鼻内类固醇滴的全身效应

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PURPOSE: To evaluate the systemic effects of intranasal steroid drops in patients with dysosmia. CASES AND METHODS: Intranasal steroid drops were administered for 12 weeks to 23 patients with dysosmia, and their plasma cortisol and adrenocorticotropic hormone (ACTH) values were measured before and after treatment. Improvement in dysosmia was judged based on the standerd olfactory test and the patients' symptoms. RESULTS: The post-treatment plasma cortisol levels ranged from 0.1 to 25.0 microg/dl (5.4 +/- 5.9 microg/dl), and the posttreatment plasma ACTH levels ranged from 5.0 to 55.0 pg/ml (13.8 +/- 11.7 pg/ml). After treatment, the 23 cases were divided into two groups: 14 cases (60.9%) with a decline in cortisol and/or ACTH level, and 9 patients (39.1%) with normal plasma cortisol and ACTH levels. Improvement in dysosmia was found in 4 patients (28.6%) in the former group and 4 patients (44.4%) in the latter group. The difference in percentage of patients who improved was not significant between the groups. CONCLUSIONS: We conclude that the direct topical effect of intranasal steroid drops on the olfactory mucosa may have been the principal reason for the improvement in the patients' dysosmia.
机译：目的：评估患有疑难血患者鼻内类固醇滴的全身效应。病例和方法：鼻内类固醇滴剂12周至23例疑似患者，并在治疗前后测量它们的血浆皮质醇和肾上腺皮质激素（ACTH）值。基于Stateerd嗅觉测试和患者的症状，判断止咳症的改善。结果：治疗后的血浆皮质醇水平范围为0.1至25.0 microg / DL（5.4 +/- 5.9 microg / DL），后处理血浆ACTH水平范围为5.0至55.0 pg / ml（13.8 +/- 11.7 pg / ml）。治疗后，将23例分为两组：14例（60.9％），皮质醇和/或acth水平下降，9例患者（39.1％），具有正常的血浆皮质醇和acth水平。在后期组和4例患者中发现了4例患者（28.6％）中发现了止咳症（28.6％）。改善的患者百分比差异在组之间不显着。结论：我们得出结论，鼻内类固醇滴对嗅粘膜的直接局部效果可能是患者呼吸困难改善的主要原因。

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