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首页> 外文会议>International Symposium on Ocular Pharmacology and Therapeutics >IOP Lowering Effects of Single Drop Application of Five Drugs Classes In Rats with Steroid-Induced Ocular Hypertension.
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IOP Lowering Effects of Single Drop Application of Five Drugs Classes In Rats with Steroid-Induced Ocular Hypertension.

机译：IOP降低了五种药物课程在类固醇诱导眼高血压大鼠大鼠中的单滴施用的影响。

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Purpose: For screening IOP lowering effects of new drugs several animal models are in use but most involve invasive techniques and are expensive. We evaluated the pharmacological utility of the rat model of steroid-induced ocular hypertension (SIOH) by studying the time course of IOP lowering by single drop application of 5 classes of antiglaucoma drugs. Methods: SIOH model was developed by bilateral topical application of dexamethasone 0.1% twice daily for 40 days after baseline IOP estimation. A rise of 20% from baseline was considered significant and these animals were included in the study. IOP lowering effect of single drop application of pilocarpine 2%, timolol 0.5%, dorzolamide 2%, brimonidine 0.2% and latanoprost 0.005% was evaluated in five groups of SIOH rats (n=8). In each group, 10mul of test drug was instilled in one eye and collateral eye served as control. IOP was estimated at regular intervals over 24 hours post-instillation. Results: Significant IOP elevation (pO.OOl) was observed in 80% of the dexamethasone treated animals at day 40. Single drop application of pilocarpine caused mean peak IOP reduction of 16.25% at 1.5 hours post-instillation. Timolol, dorzolamide and brimonidine produced mean peak IOP reduction of 19.66, 19.20 and 17.30%, respectively at 2 hours post-instillation. Peak effect of latanoprost was observed at 10 hours post-instillation and amounted to 26.91%. Conclusion: The study demonstrated that the rat model of SIOH is susceptible to changes in aqueous humor dynamics involving several different mechanisms and, therefore, is of significant pharmacological utility in screening investigational antiglaucoma agents.
机译：目的：为了筛选新药的IOP降低效果几种动物模型在使用中，但大多数涉及侵入性技术，并且是昂贵的。通过研究5类抗原瘤药物，通过研究IOP的时间过程评估类固醇诱导的眼高血压（SIOH）大鼠模型的药理效用。方法：SIOH模型由双侧局部局部应用Dexamethasone 0.1％每日两次，每天两次，40天在基线IOP估计后40天。从基线增加了20％的升高被认为是显着的，这些动物纳入研究中。 IOP降低单滴施用脱圆笋2％，蒂莫尔醇0.5％，Dorzolamide 2％，二氧化二元素0.2％和拉生素0.005％在五组SiOH大鼠（n = 8）中评价。在每组中，将10muL的试验药物滴注在一只眼睛中，并侧面用作对照。灌注后24小时以规则间隔估计IOP。结果：在第40天，在80％的地塞米松治疗动物中观察到显着的IOP升高（PO.OOL）。单滴施用脱圆萜酮在滴注后1.5小时的平均峰值降低16.25％。蒂莫尔，Dorzolamide和Brimonidine在灌注后2小时分别产生19.66,19.20和17.30％的平均峰值。在滴注后10小时观察拉谷素的峰值效应，达到26.91％。结论：该研究表明，SiOH的大鼠模型易受涉及几种不同机制的水性幽默动力学的变化，因此是筛选研究抗原瘤剂的显着药理学效用。

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