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The link between parental allergy and offspring allergic and nonallergic rhinitis

机译：父母过敏与后代变应性和非变应性鼻炎之间的联系

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Background Parental allergy-related disease increases the risk for rhinitis, but it remains unknown how different phenotypes of parental allergy affect this risk. The aim of this study was to investigate how parental hay fever, asthma, and eczema affect the risk of allergic rhinitis (AR) and nonallergic rhinitis (NAR) at 8 years of age. Methods Information on 2413 children from a population-based birth cohort was used combining questionnaire data and IgE to inhalant allergens. Logistic regression was used to estimate the association between parental allergy-related disease and AR and NAR. In addition, cluster analysis was used to search for latent phenotypes of heredity likely to be associated with AR and NAR. Results At age 8 years, 13.8% of the children had AR, while 6.4% had NAR. Parental isolated hay fever increased the odds of AR (OR 2.2, 95% CI 1.6-3.2), whereas isolated asthma or eczema did not. The odds of NAR increased when one parent had two or more allergy-related diseases. In the cluster analysis, the highest proportion of AR, 37.5%, was seen in a cluster where both parents had hay fever and pollen allergy and that of NAR, 11.0%, in a cluster where one parent had hay fever, pollen allergy, and eczema. Conclusions Parental allergy-related disease may be an important risk factor for NAR as well as AR, and the risk is comparable for maternal and paternal allergy. Parental hay fever seems to be the dominating hereditary risk factor for AR.
机译：背景与父母过敏相关的疾病会增加患鼻炎的风险，但尚不清楚父母过敏的不同表型如何影响这种风险。这项研究的目的是调查父母的花粉症，哮喘和湿疹在8岁时如何影响过敏性鼻炎（AR）和非过敏性鼻炎（NAR）的风险。方法将问卷调查数据和IgE与吸入性过敏原相结合，对2413名基于人口出生队列的儿童进行信息收集。 Logistic回归用于估计父母过敏相关疾病与AR和NAR之间的关联。此外，使用聚类分析来搜索可能与AR和NAR相关的遗传潜伏表型。结果在8岁时，有13.8％的儿童患有AR，而有6.4％的儿童患有NAR。父母孤立的花粉症增加了AR的几率（OR 2.2，95％CI 1.6-3.2），而孤立的哮喘或湿疹却没有。当一名父母患有两种或更多种与过敏相关的疾病时，NAR的几率会增加。在聚类分析中，在父母双方都有花粉过敏和花粉过敏的聚类中，AR的比例最高，为37.5％，而在父母亲有花粉过敏和花粉过敏的聚类中，NAR的比例最高，为11.0％。湿疹。结论父母过敏相关疾病可能是NAR和AR的重要危险因素，而母婴过敏的风险相当。父母花粉症似乎是AR的主要遗传危险因素。

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