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Aspirin 300 mg/day is effective for treating aspirin-exacerbated respiratory disease

机译：阿司匹林300毫克/天可有效治疗阿司匹林加重的呼吸系统疾病

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Background Aspirin desensitization (AD) treatment at doses of up to 1300 mg/day improves outcomes in aspirin-exacerbated respiratory disease (AERD). The aim of this study was to investigate the efficacy of aspirin 300 mg/day in the treatment of patients with AERD. Methods The study included 40 patients diagnosed in our clinic as AERD that were desensitized and treated with aspirin 300 mg/day between December 2005 and December 2012. Changes from the baseline status were analyzed at 1 year and at 3 years of follow-up. Results Of the 40 patients included, 24 (60%) were female and median (interquartile range [IQR]) age was 45 (40-51) years. Median (IQR) duration of AD was 31.5 (10.5-48.5) months. In total, 29 patients continued treatment for at least 1 year and 18 patients for at least 3 years. The annual rate of use of systemic corticosteroid regimens, episodes of sinusitis, and surgery was significantly lower both at 1 year (P = 0.002, P = 0.01, and P < 0.001, respectively) and at 3 years (P = 0.001, P = 0.03, and P = 0.002, respectively). Significant improvement was observed in the nasal congestion score (P = 0.01) and sense of smell score (P = 0.05) at 1 year and in the postnasal drainage score (P = 0.01) at 3 years. Conclusion Daily treatment with aspirin 300 mg had beneficial effects in patients with AERD, especially for the control of upper airway disease.
机译：背景阿司匹林脱敏（AD）的最高剂量为1300 mg /天，可改善阿司匹林加重的呼吸系统疾病（AERD）的预后。这项研究的目的是研究300 mg /天的阿司匹林在AERD患者中的疗效。方法该研究包括40例在我们诊所诊断为AERD的患者，这些患者在2005年12月至2012年12月之间接受了每天300 mg阿司匹林的脱敏治疗，并在随访1年和3年时分析了基线状态的变化。结果纳入的40例患者中，有24例（60％）为女性，中位年龄（四分位间距[IQR]）为45岁（40-51岁）。 AD的中位数（IQR）持续时间为31.5（10.5-48.5）个月。总共29例患者继续治疗至少1年，18例患者至少治疗3年。在第1年（分别为P = 0.002，P = 0.01和P <0.001）和第3年（分别为P = 0.002，P = 0.01和P <0.001），全身使用皮质类固醇疗法，鼻窦炎和手术的年使用率均显着降低。分别为0.03和P = 0.002）。 1年时鼻塞得分（P = 0.01）和嗅觉得分（P = 0.05）和3年时鼻后引流得分（P = 0.01）均有显着改善。结论每日服用300 mg阿司匹林对AERD患者有良好的疗效，尤其是对上呼吸道疾病的控制。

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