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首页> 外文期刊>Allergy >Barrier function of the nasal mucosa in health and type-2 biased airway diseases
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Barrier function of the nasal mucosa in health and type-2 biased airway diseases

机译：鼻粘膜在健康和2型偏向气道疾病中的屏障功能

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摘要

The mucosal lining of the upper airways represents the outer surface of the body to the ambient air and its contents and is prepared for it as the first line of defense. Apart from the well-described physical barrier and the mucociliary clearance, a variety of systems, including the airway microbiome, antimicrobial proteins, damage-associated molecular patterns, innate lymphoid cells, epithelial-derived cytokines and chemokines, and finally the adaptive immune system, as well as eosinophils as newly appreciated defense cells form different levels of protection against and response to any possible intruder. Of interest especially for allergic airway disease, mucosal germs might not just elicit a classical Th1/Th17-biased inflammatory response, but may directly induce a type-2 mucosal inflammation. Innovative therapeutic interventions may be possible at different levels also; however, whether modulations of the innate or adaptive immune responses will finally be more successful, and how the correction of the adaptive immune response might impact on the innate side, will be determined in the near future.
机译：上呼吸道的粘膜衬里代表人体的外表面与周围空气及其内容物的结合，并为第一道防线做好了准备。除了良好描述的物理屏障和粘膜纤毛清除作用之外，还有各种系统，包括气道微生物组，抗菌蛋白，与损伤相关的分子模式，先天性淋巴样细胞，上皮衍生的细胞因子和趋化因子，最后是适应性免疫系统，以及嗜酸性粒细胞等新近被认可的防御细胞对任何可能的入侵者形成不同程度的保护和响应。特别是对于过敏性气道疾病，粘膜细菌可能不仅引发经典的Th1 / Th17偏向的炎症反应，而且可能直接诱发2型粘膜炎症。创新的治疗干预措施也可能在不同的水平上进行;然而，将在不久的将来确定先天性免疫或适应性免疫反应的调节是否最终会更成功，以及适应性免疫反应的校正如何影响先天性。

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