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首页> 外文期刊>ACS applied materials & interfaces >Osteoinductive Fibrous Scaffolds of Biopolymer/Mesoporous Bioactive Glass Nanocarriers with Excellent Bioactivity and Long-Term Delivery of Osteogenic Drug
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Osteoinductive Fibrous Scaffolds of Biopolymer/Mesoporous Bioactive Glass Nanocarriers with Excellent Bioactivity and Long-Term Delivery of Osteogenic Drug

机译：生物聚合物/介孔生物活性玻璃纳米载体的成骨纤维支架，具有优异的生物活性和成骨药物的长期递送能力

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Designing scaffolds with bioactive composition and long-term drug delivery capacity is a promising method to improve the therapeutic efficacy in bone regeneration. Herein, electrospun fibrous scaffolds of polycaprolactone-gelatin incorporating mesoporous bioactive glass nanoparticles (mBGn) were proposed to be excellent matrix platforms for bone tissue engineering. In particular, the mBGn were loaded with osteogenic drug Dexamethasone (DEX) to elicit additional therapeutic potential. The mBGn-added fiber scaffolds demonstrated excellent properties, including improved mechanical tensile strength, elasticity, and hydrophilicity compared to pure biopolymer matrix. The scaffolds could release substantial amounts of calcium and silicate ions. The loading of DEX onto mBGn was as high as 63%, that is, 0.63 mg DEX loaded per 1 mg of mBGn, demonstrating an effective nanodepot role of the mBGn. The release of DEX from the mBGn-added fiber scaffolds was highly sustainable, profiling an almost linear release kinetics up to the test period of 28 days, after a rapid initial release of similar to 30% within 24 h. The proliferation and osteogenic differentiation of stem cells derived from periodontal ligament were significantly improved by the mBGn incorporation and synergistically stimulated with DEX loading, as confirmed by both direct and indirect cultures. The effects on bone regeneration in vivo, as analyzed by microcomputed tomography and histological stains in a rat calvarium model over 6 weeks, were substantial with the mBGn incorporation and even better with DEX loading, evidencing the osteogenic effects of the drug-eluting nanocomposite fiber scaffolds in bone formation. The current scaffolds with bone-bioactive composition and drug delivery capacity may be potentially useful for bone regeneration as novel osteogenic matrices.
机译：设计具有生物活性成分和长期药物输送能力的支架是提高骨再生治疗功效的有前途的方法。在这里，聚己内酯-明胶的静电纺丝纤维支架结合了介孔生物活性玻璃纳米颗粒（mBGn）被认为是骨组织工程的优秀基质平台。特别是，将mBGn负载成骨药物地塞米松（DEX），以激发更多的治疗潜力。与纯生物聚合物基质相比，添加mBGn的纤维支架表现出优异的性能，包括改善的机械拉伸强度，弹性和亲水性。支架可以释放大量的钙和硅酸根离子。 DEX在mBGn上的负载率高达63％，即每1 mg mBGn装载0.63 mg DEX，这证明了mBGn的有效纳米库作用。从添加mBGn的纤维支架中释放DEX是高度可持续的，在24小时内迅速释放30％左右后，直至28天的测试期间，几乎呈现线性释放动力学。直接和间接培养均证实，mBGn的掺入可显着改善源自牙周膜的干细胞的增殖和成骨分化，并通过DEX负载协同刺激。在大鼠颅骨模型中用微计算机断层扫描和组织学染色分析，在超过6周的时间内，对体内骨再生的影响很大，加入mBGn时效果显着，而在DEX负载下则更好，证明了药物洗脱纳米复合纤维支架的成骨作用。在骨形成中。当前具有骨生物活性成分和药物递送能力的支架可能作为新型成骨基质潜在地用于骨再生。

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