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首页> 外文期刊>ACS applied materials & interfaces >Bioinspired Formation of 3D Hierarchical CoFe2O4 Porous Microspheres for Magnetic-Controlled Drug Release
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Bioinspired Formation of 3D Hierarchical CoFe2O4 Porous Microspheres for Magnetic-Controlled Drug Release

机译:磁控药物释放的3D分层CoFe2O4多孔微球的生物启发形成。

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摘要

Bioinspired by the morphology of dandelion pollen grains, we successfully prepared a template-free solution-based method for the large-scale preparation of three-dimensional (3D) hierarchical CoFe2O4 porous microspheres. Besides, on the basis of the effect of the reaction time on the morphology evolution of the precursor, we proposed an in situ dissolution-recrystallization growth mechanism with morphology and phase change to understand the formation of dandelion pollenlike microspheres. Doxorubicin hydrochloride, an anticancer drug, is efficiently loaded into the CoFe2O4 microspheres. The magnetic nanoparticles as field-controlled drug carriers offer a unique power of magnetic guidance and field-triggered drug-release behavior. Therefore, 3D hierarchical CoFe2O4 porous microspheres demonstrate the great potential for drug encapsulation and controlled drug-release applications.
机译:受蒲公英花粉粒形态的启发,我们成功地制备了无模板溶液法,用于大规模制备三维(3D)分层CoFe2O4多孔微球。此外,基于反应时间对前驱物形态演化的影响,我们提出了具有形态和相变的原位溶解-重结晶生长机理,以了解蒲公英花粉状微球的形成。盐酸阿霉素(一种抗癌药物)可有效地装入CoFe2O4微球中。作为场控药物载体的磁性纳米粒子提供了独特的磁场引导和场触发药物释放行为的能力。因此,3D分层CoFe2O4多孔微球展示了用于药物封装和可控药物释放应用的巨大潜力。

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