• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>ACS applied materials & interfaces >Composite Magnetite and Protein Containing CaCO3 Crystals. External Manipulation and Vaterite -> Calcite Recrystallization-Mediated Release Performance
【24h】

Composite Magnetite and Protein Containing CaCO3 Crystals. External Manipulation and Vaterite -> Calcite Recrystallization-Mediated Release Performance

机译：含磁铁矿和蛋白质的复合碳酸钙晶体。外部操纵和球V石->方解石重结晶介导的释放性能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biocompatibility and high loading capacity of mesoporous CaCO3 vaterite crystals give an option to utilize the polycrystals for a wide range of (bio)applications. Formation and transformations of calcium carbonate polymorphs have been studied for decades, aimed at both basic and applied research interests. Here, composite multilayer-coated calcium carbonate polycrystals containing Fe3O4 magnetite nanoparticles and model protein lysozyme are fabricated. The structure of the composite polycrystals and vaterite -> calcite recrystallization kinetics are studied. The recrystallization results in release of both loaded protein and Fe3O4 nanoparticles (magnetic manipulation is thus lost). Fe3O4 nanoparticles enhance the recrystallization that can be induced by reduction of the local pH with citric acid and reduction of the polycrystal crystallinity. Oppositely, the layer-by-layer assembled poly(allylamine hydrochloride)/poly(sodium styrenesulfonate) polyelectrolyte coating significantly inhibits the vaterite -> calcite recrystallization (from hours to days) most likely due to suppression of the ion exchange giving an option to easily tune the release kinetics for a wide time scale, for example, for prolonged release. Moreover, the recrystallization of the coated crystals results in formulation of multilayer capsules keeping the feature of external manipulation. This study can help to design multifunctional microstructures with tailor-made characteristics for loading and controlled release as well as for external manipulation.
机译：介孔CaCO3球ate石晶体的生物相容性和高负载能力为在多种（生物）应用中利用多晶提供了选择。针对基础和应用研究兴趣，碳酸钙多晶型物的形成和转化已经进行了数十年的研究。在此，制备了包含Fe 3 O 4磁铁矿纳米颗粒和模型蛋白溶菌酶的复合多层涂覆的碳酸钙多晶体。研究了复合多晶体的结构和球v石→方解石的再结晶动力学。重结晶导致负载的蛋白质和Fe3O4纳米颗粒的释放（因此失去了磁性操作）。 Fe 3 O 4纳米颗粒增强了重结晶，该重结晶可通过柠檬酸降低局部pH值和降低多晶结晶度来诱导。相反，逐层组装的聚（烯丙胺盐酸盐）/聚（苯乙烯磺酸钠）聚电解质涂层显着抑制了球v石->方解石重结晶（从数小时到数天），这很可能是由于抑制了离子交换，从而提供了一个容易选择的选择在较宽的时间范围内调整释放动力学，例如延长释放时间。而且，包被的晶体的重结晶导致形成多层胶囊，其保留了外部操作的特征。这项研究可以帮助设计具有量身定制的功能的多功能微结构，以进行加载和控制释放以及外部操纵。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号