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首页> 外文期刊>ACS applied materials & interfaces >Suspended, Shrinkage-Free, Electrospun PLGA Nanofibrous Scaffold for Skin Tissue Engineering
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Suspended, Shrinkage-Free, Electrospun PLGA Nanofibrous Scaffold for Skin Tissue Engineering

机译：悬浮，无收缩的静电纺PLGA纳米纤维支架，用于皮肤组织工程

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摘要

Electrospinning is a technique far creating, continuous nanofibrous networks that can architecturally be similar to the structure. of extracellular matrix (ECM). However, the shrinkage of electrospun mats is unfavorable for the triggering of cell adhesion and further growth. In this work, electrospun PLGA nanofiber assemblies are utilized to create a scaffold. Aided by a polypropylene auxiliary supporter, the scaffold is able to maintain long-term integrity without dimensional shrinkage. This scaffold is also able to suspend in cell culture medium; hence, keratinocyte cells seeded on the scaffold are exposed to air as required in skin tissue, engineering. Experiments also Show that human skin keratinocytes can proliferate on the scaffold and infiltrate into the scaffold.
机译：电纺丝是一种技术，它可以创建连续的纳米纤维网络，该网络在结构上可以与结构相似。细胞外基质（ECM）。然而，电纺垫的收缩对于触发细胞粘附和进一步生长是不利的。在这项工作中，静电纺PLGA纳米纤维组件被用来创建支架。在聚丙烯辅助支撑器的辅助下，该支架能够保持长期的完整性而不会发生尺寸收缩。该支架也能够悬浮在细胞培养基中。因此，根据皮肤组织工程需要，将接种在支架上的角质形成细胞暴露于空气中。实验还表明，人皮肤角质形成细胞可以在支架上增殖并渗入支架。

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