...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>藥學雜誌 >Study on the effectiveness of rapid and simple methods for analysis of pesticides causing acute poisoning in emergency medicine
【24h】

Study on the effectiveness of rapid and simple methods for analysis of pesticides causing acute poisoning in emergency medicine

机译：急诊医学中急性中毒急性中毒分析快速简便方法的效果研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Quick detection of substances causing acute poisoning is often difficult. There is a need for methods that allow rapid detection of pesticides causing acute poisoning, which is often severe and has a high mortality rate, for quick diagnosis and appropriate treatment. The aim of this study was therefore to develop rapid and simple analytical methods for detecting acute poisoning-inducing substances in samples of stomach contents, returned gastric lavage solution, serum, or urine using an analytical device that can be used in the field as well as in pharmaceutical divisions and emergency medical units. We first examined the effectiveness of a screening method using TLC and then the effectiveness of HPLC equipped with a photo-diode array detector (HPLC-DAD) for qualitative and quantitative measurements. In the former technique, we were able to develop a rapid and simple screening method by adjusting the TLC plate and development solvent. In the latter technique, we were able to establish rapid and accurate methods for qualitative and quantitative measurements by using a column-switching technique in which a sample is injected directly into the column without pretreatment. Results of tests using actual samples obtained from patients with acute poisoning showed that the time required for detection using these techniques (less than 1 h) was much shorter than that required using conventional techniques. The use of these techniques should reduce the mortality rate in cases of acute poisoning, since physicians would be able to receive prompt advice regarding diagnosis, prognosis, and treatment methods. We have also designed a practical system for analysis of acute poisoning-inducing pesticides.
机译：快速检测导致急性中毒的物质通常很困难。需要允许快速检测引起急性中毒的农药的方法，这通常严重并具有高死亡率，用于快速诊断和适当的治疗。因此，本研究的目的是利用可在现场使用的分析装置以及可以在领域中使用的分析装置来发育快速和简单的分析方法，用于检测胃内容物的样品，返回的胃灌洗液，血清或尿液中的急性中毒诱导物质。在制药部门和紧急医疗单位。我们首先检查了使用TLC筛选方法的有效性，然后通过配备有光电二极管阵列检测器（HPLC-DAD）的HPLC的有效性进行定性和定量测量。在前一种技术中，我们通过调节TLC板和显影溶剂，我们能够开发快速和简单的筛选方法。在后一种技术中，我们能够通过使用柱切换技术来建立快速和准确的定性和定量测量方法，其中样品直接注入柱子而不预处理。使用从急性中毒患者获得的实际样品的试验结果表明，使用这些技术（小于1小时）检测所需的时间比使用常规技术所需的时间短得多。这些技术的使用应降低急性中毒病例的死亡率，因为医生能够接受有关诊断，预后和治疗方法的促进建议。我们还设计了一种实用的系统，用于分析急性中毒诱导的杀虫剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号