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首页> 外文期刊>藥學雜誌 >Mechanism of cell proliferation--cell cycle, oncogenes, and senescence
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Mechanism of cell proliferation--cell cycle, oncogenes, and senescence

机译：细胞增殖的机制 - 细胞周期，癌基因和衰老

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Cell proliferation is regulated through a transition between the G0 phase and cell cycle. We isolated a mammalian temperature-sensitive mutant cell line defective in the function from the G0 phase to cell cycle. Senescent human somatic cells fail to enter into the cell cycle from the G0 phase with stimulation by any growth factor. Telomere shortening was found to be a cause of cellular senescence, and reexpression of telomerase immortalized human somatic cells. Immortalized human somatic cells showed normal phenotypes and were useful not only for basic research but also for clinical and applied fields. The importance of p53 and p21 activation/induction i now well accepted in the signal transduction process from telomere shortening to growth arrest, but the precise mechanism is largely unknown as yet. We found that the MAP kinase cascade and histone acetylase have an important role in the signaling process to express p21. Tumor tissues and cells were found to have strong telomerase activity, while most normal somatic human tissues showed very weak or no activity. Telomerase activity was shown to be a good marker for early tumor diagnosis because significant telomerase activity was detected in very early tumors or even in some precancerous tissues compared with adjacent normal tissues. Telomere/telomerase is a candidate target for cancer chemotherapeutics, and an agent that abrogated telomere functions was found to kill tumor cells effectively by inducing apoptosis whereas it showed no effect on the viability of normal cells.
机译：通过G0相和细胞周期之间的转变来调节细胞增殖。我们将哺乳动物温度敏感突变体细胞系分离出在从G0相到细胞周期的功能中缺陷。衰老人体细胞未通过任何生长因子刺激从G0相进入细胞周期。发现眼极缩短是细胞衰老的原因，并且端粒酶的重复压缩是永生化的人体细胞。永生化的人体细胞显示正常表型，不仅适用于基础研究，还可用于临床和应用领域。 P53和P21激活/感应的重要性我现在在信号转导过程中接受了从端粒缩短到生长停滞的信号转导过程，但精确的机制很大程度上是未知的。我们发现地图激酶级联和组蛋白乙酰化酶在信号处理过程中具有重要作用，以表达P21。发现肿瘤组织和细胞具有强烈的端粒酶活性，而大多数正常的体细胞组织表现出非常弱或无活性。将端粒酶活性显示为早期肿瘤诊断的良好标志物，因为与相邻的正常组织相比，在非常早期的肿瘤中或甚至在一些癌前组织中检测到显着的端粒酶活性。端粒/端粒酶是癌症化学治疗剂的候选靶标，通过诱导细胞凋亡，发现消毒功能的药剂有效地杀死肿瘤细胞，而它对正常细胞的活力没有影响。

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