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首页> 外文期刊>診療と新薬 >EFFECT OF ALCOHOL-METABOLIZING STIMULATION, AND EFFICACY OF LIVER FUNCTION AND SAFETY BY INGESTION OF SUPPLEMENT CONTAINING FRESHWATER CLAM EXTRACTIVE
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EFFECT OF ALCOHOL-METABOLIZING STIMULATION, AND EFFICACY OF LIVER FUNCTION AND SAFETY BY INGESTION OF SUPPLEMENT CONTAINING FRESHWATER CLAM EXTRACTIVE

机译：含有淡水蛤蜊萃取的补充剂的醇代谢刺激的影响，肝功能和安全性和肝功能

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Objectives: Freshwater Clam Extract (FCE) and Pork Liver Extract (PLE) contain various functional amino acids such as L-ornithine and Alanine. L-ornithine is an amino acid which stimulates the urea cycle in the liver. Alcohol intake transiently increases blood ammonia levels. Both ammonia and alcohol are toxic and mainly metabolized in the liver. Therefore, metabolism of alcohol and ammonia has an important role on physiological states after consumption of alcohol. The purpose of this study was to assess the efficacy and safety of a supplement containing FCE and PLE in healthy subjects after alcohol intake.Methods: A randomized, placebo-controlled, double-blind crossover study was conducted to evaluate the utility of the test product in healthy subjects after alcohol intake (STUDY 1).The test product contains FCE and PLE including L-ornithine and Alanine per 310 mg/ tablet. After 7 days ingestion of the test product and placebo, subjects consumed a certain amount of alcohol. Subjective symptoms after alcohol intake, and the condition of the subjects the following morning were evaluated based on questionnaires. Blood hepatic markers and ethanol concentration were measured. The safety of the test product was evaluated through two methods. One method was based on blood biochemical parameters and a diary that recorded the lifestyle of the subject and adverse events (STUDY1).The other method evaluated the safety of excessive intake (five times higher than the recommended daily dosage) of the test product (STUDY 2).
机译：目的：淡水蛤蜊提取物（FCE）和猪肝提取物（PLE）含有各种官能氨基酸，如L-鸟氨酸和丙氨酸。 L-鸟氨酸是刺激肝脏中尿素循环的氨基酸。酒精摄入瞬时增加血液氨水位。氨和酒精均毒性，主要在肝脏中代谢。因此，酒精和氨的代谢对酒精消耗后的生理状态具有重要作用。本研究的目的是评估酒精摄入后健康受试者含有FCE和PLE的补充剂的疗效和安全性。方法：进行随机，安慰剂控制的双盲交叉研究，评价试验产品的效用在酒精摄入后的健康受试者中（研究1）。试验产品含有FCE和PLE，包括每310 mg /平板电脑的L-鸟氨酸和丙氨酸。摄入7天后摄入试验产品和安慰剂后，受试者消耗了一定量的酒精。酒精摄入后的主观症状，并根据问卷评估第二天早晨的受试者的状况。测量血液肝脏标记和乙醇浓度。通过两种方法评价试验产品的安全性。一种方法基于血液生化参数和记录受试者的生活方式的日记和不良事件（研究1）。其他方法评估了测试产品的过度摄入的安全性（比推荐的每日剂量高五倍）（研究2）。

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