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首页> 外文期刊>診療と新薬 >Efficacy of Supplements on the Condition of the Human Skin Containing Soybean Isoflavonin in Healthy Japanese Women: A Randomized Double-blind Placebo-controlled Study
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Efficacy of Supplements on the Condition of the Human Skin Containing Soybean Isoflavonin in Healthy Japanese Women: A Randomized Double-blind Placebo-controlled Study

机译：补充剂对健康日本女性大豆异黄酮含有大豆异黄酮的病情的疗效：随机双盲安慰剂对照研究

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Objective: The objective of this research was to investigate the effectiveness of daily ingestion of food containing soybean isoflavon, on the condition of the human skin.Methods:A randomized, placebo-controlled, double-blind study was conducted to verify the skin condition. In this study we measured wrinkles, the amount of surface spots (surface spots and hidden ones), the amount of melanin, the whiteness of the complexion, the stratum corneum hydration (SCH) and the trans-epidermal water loss (TEWL), and also carried out the subjective reporting in form of a questionnaire. To evaluate the safety of the test foods, adverse events were collected by means of a written questionnaire during the study. Results: From all of 151 applicants,110 were eliminated due to not meeting inclusion criteria. The 41 subjects were randomly assigned to intervention groups and made a start with ingestion. None were withdrawn and all 41 subjects completed the study. Thus, data obtained from 41 subjects (Test;19， Placebo; 22) were used for efficacy analysis. After the 12-weeks of ingestion Test showed a significant difference in "wrinkle grade" and "The stratum corneum hydration (SCH)", and showed an improvement tendency in "The whiteness of complexion (L*)", compared to the Placebo. On the other hand, the tendency was not seen in "spots" or "melanin". As for the subjective evaluation, we observed a significant difference in 6 out of 20 items. No adverse effects were observed after the ingestion of the test product. Conclusion: We found out that the ingestion of the food containing Aglycone-type soybean isoflavone high in daidzein for 12 weeks contributed to the improvement of items related to resilience, tightness and/or moisture of skin. In addition, no safety-related matter occurred during the 12-week test period.
机译：目的：本研究的目的是探讨含有大豆异黄酮的食物的每日摄入的有效性，对人体皮肤的条件。方法：进行随机，安慰剂控制的双盲研究以验证皮肤状况。在这项研究中，我们测量了皱纹，表面斑点（表面斑点和隐藏的量），黑色素的量，肤色的白度，角质层水合（SCH）和反向表皮水分（Tewl），以及还以问卷的形式进行了主观报告。为了评估测试食品的安全性，通过研究期间通过书面调查问卷收集不良事件。结果：由于不符合纳入标准，从151名申请人中消除了110个。将41个受试者随机分配到干预组，并以摄入开始。没有被撤回，所有41名受试者都完成了这项研究。因此，从41个受试者获得的数据（测试; 19，安慰剂; 22）用于功效分析。 12周的摄入试验后，与安慰剂相比，“皱纹级”和“皱纹级”和“角质层水合（SCH）”呈现出改善趋势。另一方面，在“斑点”或“黑色素”中没有看到趋势。至于主观评价，我们观察到20个项目中的6个显着差异。摄入测试产品后没有观察到不利影响。结论：我们发现，摄入含有糖苷酮型大豆异黄酮的食物12周，为改善了与皮肤的韧带，紧绷和/或水分相关的物品有助于改善。此外，在12周测试期间没有发生安全相关的物质。

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