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首页> 外文期刊>ACS applied materials & interfaces >A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture
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A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture

机译：使用拆分的G四联体选择性铱（III）配合物和三向DNA连接体系结构的可卡因发光检测平台。

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摘要

In this study, a series of 10 in-house cyclometalated iridium(III) complexes bearing different auxiliary ligands were tested for their selectivity toward split G-quadruplex in order to construct a label-free switch-on cocaine detection platform employing a three-way junction architecture and a G-quadruplex motif as a signal output unit. Through two rounds of screening, we discovered that the iridium(III) complex 7 exhibited excellent selectivity toward the intermolecular G-quadruplex motif. A detection limit as low as 30 nM for cocaine can be achieved by this sensing approach with a linear relationship between luminescence intensity and cocaine concentration established from 30 to 300 nM. Furthermore, this sensing approach could detect cocaine in diluted oral fluid. We hope that our simple, signal-on, label-free oligonucleotide-based sensing method for cocaine using a three-way DNA junction architecture could act as a useful platform in bioanalytical research.
机译：在这项研究中，测试了一系列带有不同辅助配体的10种内部环金属化铱（III）配合物对分裂G-四链体的选择性，以构建采用三向反应的无标记可卡因检测平台连接结构和一个G四重主题作为信号输出单元。通过两轮筛选，我们发现铱（III）配合物7对分子间G四联体基序表现出出色的选择性。通过这种检测方法，可卡因的检测限可低至30 nM，并且发光强度与可卡因浓度之间的线性关系为30至300 nM。此外，这种感测方法可以检测稀释的口腔液中的可卡因。我们希望我们使用三向DNA连接结构的可卡因的简单，无信号，无标记的基于寡核苷酸的传感方法，可以作为生物分析研究的有用平台。

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