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首页> 外文期刊>Allergy & clinical immunology international: official organ of the International Association of Allergology and Clinical Immunology >Encasing Study in Mite-allergic Patients: One-Year, Double-blind, Placebo and Environment-controlled Investigation
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Encasing Study in Mite-allergic Patients: One-Year, Double-blind, Placebo and Environment-controlled Investigation

机译：螨过敏患者的相关研究：一年，双盲，安慰剂和环境对照研究

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Background: The reduction of house dust mite (HDM) allergen exposure is established in the management of HDM allergy, but the clinical benefit of HDM prevention measures is not well documented. The purpose of this study was to evaluate the efficacy of encasing mattresses, pillows, and duvets or blankets as a single measure against mite allergy symptoms. Methods: In this one-year, placebo-controlled, double-blind study, mite-allergic volunteers encased bedding in allergen-impermeable or permeable covers. The severity of clinical allergy symptoms was measured in terms of a daily symptom score at the beginning and at the end of the trial. We also analyzed morning peak flow values and eosinophil cationic protein (ECP) levels. Results: A clinical benefit was documented for all volunteers using allergen-impermeable covers, and for 7 of 11 volunteers using permeable placebo covers. There was a statistically significant decrease in the score of the symptom load only in the group of volunteers using the impermeable covers. Significant effects on morning peak flow and ECP values were not observed. Conclusion: Our study demonstrates that encasings can reduce allergy symptoms in mite-allergic patients. For some patients this can be an adequate therapy on its own. We therefore recommend the installation of encasements as a first step in the management of mite allergy.
机译：背景：减少HDM过敏原已被确定为HDM过敏的管理方法，但HDM预防措施的临床益处尚无充分记载。这项研究的目的是评估包装床垫，枕头，羽绒被或毯子作为对抗螨过敏症状的单一措施的功效。方法：在这项为期一年的安慰剂对照，双盲研究中，螨虫过敏志愿者将被褥包裹在过敏原不可渗透或可渗透的覆盖物中。根据试验开始和结束时的每日症状评分来衡量临床过敏症状的严重程度。我们还分析了早晨的峰值流量值和嗜酸性粒细胞阳离子蛋白（ECP）水平。结果：已记录了使用不渗透变应原覆盖物的所有志愿者以及使用可渗透性安慰剂覆盖物的11名志愿者中的7名的临床获益。仅在使用不透水覆盖物的志愿者组中，症状负荷评分有统计学上的显着下降。没有观察到对早晨高峰流量和ECP值的显着影响。结论：我们的研究表明，套袋可以减轻螨虫过敏患者的过敏症状。对于某些患者而言，这本身可能是一种足够的治疗方法。因此，我们建议安装包装盒，作为管理螨过敏的第一步。

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