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首页> 外文期刊>Allergy & clinical immunology international: official organ of the International Association of Allergology and Clinical Immunology >Novel Functions of Two Chemokines in Allergic Disease: Thymus and Activation-regulated Chemokine (TARC)/CCL17 and Macrophage-derived Chemokine (MDC)/CCL22
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Novel Functions of Two Chemokines in Allergic Disease: Thymus and Activation-regulated Chemokine (TARC)/CCL17 and Macrophage-derived Chemokine (MDC)/CCL22

机译：两种趋化因子在变应性疾病中的新功能：胸腺和激活调节趋化因子（TARC）/ CCL17和巨噬细胞衍生趋化因子（MDC）/ CCL22

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Background: T helper (Th) 2 cells are considered to have a critical role in the pathogenesis of bronchial asthma. Th2 cells are recruited into the airway mucosa of patients with asthma. Chemokines are involved not only in regulating leukocyte recruitment, but also in other activities, such as cellular activation, inflammatory mediator release, and promotion of Th2 inflammatory responses. However, functions other than cell recruitment remain poorly understood. Methods/Data base: Since we have already shown that the production of thymus and activation-regulated chemokine (TARC)/CCL17 and macrophage-derived chemokine (MDC)/CCL22, CC-chemokines produced by CD4+ T cells stimulated with both anti-CD3 and anti-CD28 antibodies was higher in asthmatic patients than in healthy controls, we examined effects of TARC/CCL17 and MDC/CCL22, on naive CD4+ T cells expressing CCR4 (a receptor for CCL17 and CCL22) during differentiation of Th1 and Th2 cells in asthmatic patients. Results/Conclusion: Surprisingly, proliferation of activated naive CD4+ T cells after stimulation in either a default condition or a Th1 or Th2 condition was much greater in asthmatics than in normal controls. Such proliferation was inhibited by CCR4-blockades. Exogenous CCL17 and CCL22 apparently functioned as proliferation and antiapoptotic factors for activated naive CD4+ T cells in each condition. Available evidence suggests that CCL17 and CCL22 produced by naive CD4+ T cells in asthma might contribute to cell proliferation by means of autocrine loops that promote both antiapoptosis and proliferation during differentiation of T cells to effector cells.
机译：背景：T辅助（Th）2细胞被认为在支气管哮喘的发病机理中具有关键作用。 Th2细胞被募集到哮喘患者的气道粘膜中。趋化因子不仅参与调节白细胞募集，还参与其他活动，例如细胞活化，炎症介质释放和Th2炎症反应的促进。但是，除细胞募集以外的功能仍知之甚少。方法/数据库：由于我们已经证明了胸腺和激活调节趋化因子（TARC）/ CCL17以及巨噬细胞衍生趋化因子（MDC）/ CCL22的产生，CD4 + T细胞产生的CC趋化因子均被两种抗CD3刺激哮喘患者的抗CD28抗体高于健康对照者，我们研究了TARC / CCL17和MDC / CCL22对Th1和Th2细胞分化过程中表达CCR4（CCL17和CCL22受体）的幼稚CD4 + T细胞的影响。哮喘患者。结果/结论：令人惊讶的是，哮喘患者在默认条件或Th1或Th2条件下刺激后激活的天然CD4 + T细胞的增殖比正常对照组大得多。这种增殖被CCR4-阻断抑制。在每种情况下，外源CCL17和CCL22显然充当活化的天然CD4 + T细胞的增殖和抗凋亡因子。现有证据表明，哮喘中的幼稚CD4 + T细胞产生的CCL17和CCL22可能通过自分泌环促进细胞增殖，该自分泌环在T细胞分化为效应细胞的过程中既促进抗凋亡又促进增殖。

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