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首页> 外文期刊>Allergy & clinical immunology international: official organ of the International Association of Allergology and Clinical Immunology >Inverse Correlation of the Urine Biomarker for Benzene Exposure and CD4+ T-Lymphocyte Count in Traffic Policemen
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Inverse Correlation of the Urine Biomarker for Benzene Exposure and CD4+ T-Lymphocyte Count in Traffic Policemen

机译：交警中尿液生物标志物与苯暴露和CD4 + T-淋巴细胞计数的反相关

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摘要

Benzene exposure can result in chronic toxicity including aberration of the immune system. This study was set to determine the CD4+ count and its correlation to the novel urine biomarker for benzene exposure in urine, trans, trans-muconic acid (tt-MA), among a sample of Thai traffic policemen. A total of 39 policemen (all male) were included in this study. The average CD4+ count in these policemen was 21.2 +- 8.1 %. Concerning the regression analysis, the least square equation plot CD4+ count (Y) vs. urine ttMA (X) was 42 - 12X (r = .92, p = .04). The correlation study between urine ttMA and CD4+ count in this study showed a significant correlation. It implies that high exposure, estimated from high urine ttMA, suppresses CD4+ count. Of interest, monitoring for benzene exposure among at-risk workers is recommended. In cases with high urine ttMA from screening, special consideration should be given to the risk for immune impairment.
机译：苯接触可导致慢性毒性，包括免疫系统异常。这项研究的目的是确定泰国交通警察样本中CD4 +的计数及其与尿液中苯暴露的新型尿液生物标志物，反式，反式粘康酸（tt-MA）的相关性。这项研究总共包括39名警察（均为男性）。这些警察的平均CD4 +计数为21.2±8.1％。关于回归分析，最小二乘方程图CD4 +计数（Y）对尿液ttMA（X）为42-12X（r = .92，p = .04）。尿ttMA与CD4 +计数之间的相关性研究显示出显着的相关性。这意味着从高尿液ttMA估计的高暴露量会抑制CD4 +计数。有趣的是，建议对有风险的工人进行苯接触监测。如果筛查尿ttMA较高，则应特别考虑免疫功能受损的风险。

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