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首页> 外文期刊>Allergy & clinical immunology international: official organ of the International Association of Allergology and Clinical Immunology >IgE Antibody Responses to Recombinant Allergens of Blomia tropicalis and Dermatophagoides pteronyssinus in a Tropical Environment
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IgE Antibody Responses to Recombinant Allergens of Blomia tropicalis and Dermatophagoides pteronyssinus in a Tropical Environment

机译：在热带环境中，IgE抗体对热带大花and和Dermatophagoides pteronyssinus重组变应原的应答

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Background: Dermatophagoides pteronyssinus and Blomia tropicalis are the major sensitizer mite species in tropical regions. Several allergens from these species have been obtained by molecular cloning. In order to use them in clinical practice, evaluation of their allergenic potential in different populations is mandatory. This study evaluates the clinical significance and allergenicity of several recombinant allergens from B. tropicalis and D. pteronyssinus in asthmatic patients from a tropical environment. Methods/Data base: Specific IgE to allergenic extracts of D. pteronyssinus and B. tropicalis and to the recombinant allergens BtM, a peptide homologue to Blo t 5, Blo t 1, Blo t 13, Der p , Der p 5, Der p 7, and Der p 10 as well as the natural Der p 1 (nDer p 1), was determined by radioallergosorbent test (RAST) in sera from 90 asthmatic patients and 10 healthy controls. In addition, SPT was performed in a selected group of patients. Results: The prevalence of reactivity to D. pteronyssinus and B. tropicalis extracts was 86.6% and 84.4%, respectively. The frequency of positive RAST to each D. pteronyssinus allergen was as follows: Der p , 68.9%; Der p , 64.4%; Der p 5, 37.8%; Der p 10, 16.7% and Der p 7, 15.6%. The frequency of positive RAST to B. tropicalis allergens was as follows: BtM, 42.2%; Blo t 1, 16.7% and Blo t 13, 11.1%. Together, Der p , Der p , and Der p 10 were able to detect 93.5% of D. pteronyssinus allergic subjects. Via skin testing, all 8 mite allergens induced positive reactions in the selected allergic patients and negative results among the nine non-allergic subjects. Conclusions: The recombinant allergens tested are potentially useful as tools for in vitro and in vivo testing of mite allergy. Together, three recombinant allergens were able to detect 93% of D. pteronyssinus allergic subjects.
机译：背景：鹿角皮病和热带Blomia是热带地区主要的致敏螨类。通过分子克隆从这些物种获得了几种过敏原。为了在临床实践中使用它们，必须评估它们在不同人群中的致敏潜力。这项研究评估了热带环境中哮喘患者中热带双歧杆菌和蕨类植物的几种重组变应原的临床意义和致敏性。方法/数据库：特异的翼状p肉和热带双歧杆菌的过敏原提取物以及重组变应原BtM的特异性IgE，BtM是与Blo t 5，Blo t 1，Blo t 13，Der p，Der p 5，Der p同源的肽如图7所示，在90名哮喘患者和10名健康对照者的血清中，通过放射变态吸附试验（RAST）确定了Der p 10以及天然Der p 1（nDer p 1）。此外，在选定的一组患者中进行了SPT。结果：对蕨类植物假单胞菌和热带双歧杆菌提取物的反应性分别为86.6％和84.4％。对每个蕨类植物过敏原的阳性RAST频率如下：Der p，68.9％; Der p，64.4％; Der p 5，37.8％; Der p 10，16.7％和Der p 7，15.6％。 RAST阳性的热带双歧杆菌过敏原的频率如下：BtM，42.2％;占1、16.7％和占13、11.1％。 Der p，Der p和Der p 10一起可以检测出93.5％的蕨类植物过敏原受试者。通过皮肤测试，所有8种螨过敏原在选定的过敏患者中均诱发阳性反应，而在9名非过敏受试者中则诱导阴性结果。结论：测试的重组变应原可能作为螨过敏的体外和体内测试的工具。三种重组变应原一起能够检出93％的蕨类植物过敏原受试者。

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