...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Kidney Diseases: The official journal of the National Kidney Foundation >Recurrent proliferative glomerulonephritis with monoclonal IgG deposits of IGG2λ subtype in a transplanted kidney: A case report
【24h】

Recurrent proliferative glomerulonephritis with monoclonal IgG deposits of IGG2λ subtype in a transplanted kidney: A case report

机译：移植肾中复发性增生性肾小球肾炎伴有IGG2λ亚型的单克隆IgG沉积物：一例报告

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a recently described disease entity. In the kidney transplantation literature, only 6 recurrent and 2 de novo PGNMID cases, including 7 of the IgG3 subclass (6 with κ light chain and 1 with λ light chain) and 1 of the IgG1 subclass (λ light chain), have been described to date. We describe a 52-year-old man with end-stage renal disease whose primary glomerular disease had been suggested to be membranoproliferative glomerulonephritis. The patient underwent living related donor kidney transplantation and presented with proteinuria, hematuria, and decreased kidney function at 4 months posttransplantation. Biopsy of the transplanted kidney showed diffuse endocapillary proliferative glomerulonephritis. Immunofluorescence microscopy showed prominent granular glomerular staining for IgG, C3, and λ light chain, with IgM, IgA, and κ light chain undetectable. Immunofluorescence staining for IgG subclass showed signal for IgG2 only. Retrospective analysis of the native kidney biopsy specimen also showed the same monoclonal glomerular staining for the IgG2λ subtype. These findings led us to the diagnosis of PGNMID of the IgG2λ subtype as both the primary glomerular disease and recurrent disease in the transplanted kidney. Recurrence was treated with high-dose prednisolone, which decreased proteinuria, hematuria, and serum creatinine level. The case demonstrates that PGNMID of the IgG2λ subtype also can recur in the transplanted kidney.
机译：具有单克隆免疫球蛋白G（IgG）沉积物（PGNMID）的增生性肾小球肾炎是最近描述的疾病实体。在肾脏移植文献中，仅描述了6例复发和2例从头开始的PGNMID病例，其中包括7个IgG3亚类（6个具有κ轻链和1个具有λ轻链）和1个IgG1亚类（λ轻链）。至今。我们描述了一名患有终末期肾脏疾病的52岁男性，其原发性肾小球疾病被认为是膜增生性肾小球肾炎。该患者接受了与生活有关的供体肾脏移植，移植后4个月出现蛋白尿，血尿和肾功能下降。移植肾的活检显示弥漫性毛细血管内增生性肾小球肾炎。免疫荧光显微镜检查显示，IgG，C3和λ轻链有明显的颗粒状肾小球染色，无法检测到IgM，IgA和κ轻链。 IgG亚类的免疫荧光染色仅显示IgG2的信号。对天然肾脏活检标本的回顾性分析还显示了IgG2λ亚型的相同的单克隆肾小球染色。这些发现使我们诊断出IgG2λ亚型的PGNMID是移植肾中的原发性肾小球疾病和复发性疾病。用大剂量泼尼松龙治疗复发，可降低蛋白尿，血尿和血清肌酐水平。该病例表明，IgG2λ亚型的PGNMID也可以在移植的肾脏中复发。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号