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首页> 外文期刊>American Journal of Kidney Diseases: The official journal of the National Kidney Foundation >Recent Advances in Traditional Chinese Medicine for Kidney Disease
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Recent Advances in Traditional Chinese Medicine for Kidney Disease

机译：肾病中药研究新进展

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Because current treatment options for chronic kidney disease (CKD) are limited, many patients seek out alternative therapies such as traditional Chinese medicine. However, there is a lack of evidence from large clinical trials to support the use of traditional medicines in patients with CKD. Many active components of traditional medicine formulas are undetermined and their toxicities are unknown. Therefore, there is a need for research to identify active compounds from traditional medicines and understand the mechanisms of action of these compounds, as well as their potential toxicity, and subsequently perform well-designed, randomized, controlled, clinical trials to study the efficacy and safety of their use in patients with CKD. Significant progress has been made in this field within the last several years. Many active compounds have been identified by applying sophisticated techniques such as mass spectrometry, and more mechanistic studies of these compounds have been performed using both in vitro and in vivo models. In addition, several well-designed, large, randomized, clinical trials have recently been published. We summarize these recent advances in the field of traditional medicines as they apply to CKD. In addition, current barriers for further research are also discussed. Due to the ongoing research in this field, we believe that stronger evidence to support the use of traditional medicines for CKD will emerge in the near future. (C) 2015 by the National Kidney Foundation, Inc.
机译：由于目前对慢性肾脏病（CKD）的治疗选择有限，因此许多患者寻求替代疗法，例如中药。但是，缺乏大型临床试验的证据来支持在CKD患者中使用传统药物。传统药物配方的许多活性成分尚未确定，其毒性未知。因此，需要进行研究以从传统药物中鉴定出活性化合物，并了解这些化合物的作用机理及其潜在毒性，然后进行精心设计，随机，对照的临床试验，以研究其功效和有效性。在CKD患者中使用它们的安全性。在过去的几年中，该领域已取得重大进展。已经通过应用复杂的技术（例如质谱法）鉴定了许多活性化合物，并且已经使用体外和体内模型对这些化合物进行了更多的机理研究。此外，最近还发布了一些精心设计的大型随机临床试验。我们总结了应用于CKD的传统医学领域的最新进展。此外，还讨论了进一步研究的当前障碍。由于该领域的持续研究，我们相信在不久的将来将会出现更强有力的证据来支持将传统药物用于CKD。 （C）美国国家肾脏基金会，2015年。

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